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Keywords: Embryonic stem cell
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Journal Articles
Journal: Development
Development (2018) 145 (4): dev156836.
Published: 14 February 2018
...: Embryonic stem cell-derived presomitic mesoderm-like tissues exhibit synchronized Hes7 oscillations, anterior-posterior-like axis formation and segment formation, and are suitable for chemical-library screening for detailed analysis of the segmentation clock. Chemical library screening Embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 12–16.
Published: 01 January 2017
... no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 Summary: This Meeting Review summarises the major themes and results presented at the second 'From Stem Cells to Human Development' meeting, held in October 2016. Development Embryonic stem cell...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1571–1584.
Published: 01 May 2016
... characterized by loss of heterochromatin, activation of tandem repeats, oxidative stress and Rip3-associated necroptosis. In the human retina, BMI1 was preferentially expressed in cones at heterochromatic foci. BMI1 inactivation in human embryonic stem cells was compatible with retinal induction but impaired...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 24–34.
Published: 01 January 2016
... a minority of the embryonic stem cell (ESC) inoculum contributes to the adult chimaera. How incoming cells are chosen for integration or elimination remains unclear. By comparing a heterogeneous mix of undifferentiated and differentiating ESCs (serum/LIF) with more homogeneous undifferentiated culture (2i...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3488–3499.
Published: 15 October 2015
...Sophie M. Morgani; Joshua M. Brickman Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3113–3125.
Published: 15 September 2015
...Meritxell Huch; Bon-Kyoung Koo In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study tissue development, organogenesis and stem cell behavior ex vivo . When grown in a 3D environment, embryonic stem cells (ESCs) self-organize into organoids and acquire the right...
Journal Articles
Journal: Development
Development (2015) 142 (5): 846–857.
Published: 01 March 2015
...Guang Li; Karolina Plonowska; Rajarajan Kuppusamy; Anthony Sturzu; Sean M. Wu The transcriptional profiles of cardiac cells derived from murine embryos and from mouse embryonic stem cells (mESCs) have primarily been studied within a cell population. However, the characterization of gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 431–437.
Published: 01 February 2015
...Satoshi Ohtsuka; Hitoshi Niwa The requirement of leukemia inhibitory factor (LIF) for the establishment and maintenance of mouse embryonic stem cells (ESCs) depends on the genetic background of the ESC origin. To reveal the molecular basis of the strain-dependent function of LIF, we compared...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4285–4297.
Published: 15 November 2014
..., 1998 ; Yoon et al., 2000 ; Yoon and Wold, 2000 ). However, gain-of-function studies on Tbx6 in mice ( Wehn and Chapman, 2010 ) and T in embryonic stem cells (ESCs) ( Lindsley et al., 2008 ) do not reveal strong mesoderm-inducing activity, raising the question as to what is the major positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 784–794.
Published: 15 February 2014
... is known about how this crucial subtype of motor neuron is generated during embryogenesis. Here, we used direct differentiation of motor neurons from mouse embryonic stem cells as a tool to identify genes that direct phrenic neuron identity. We find that three determinants, Pou3f1, Hoxa5 and Notch, act...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2597–2610.
Published: 15 June 2013
... there is access to appropriate tissue and sufficient numbers of articular chondrocytes. Embryonic stem cells (ESCs) represent a potentially unlimited source of chondrocytes and tissues as they can generate a broad spectrum of cell types under appropriate conditions in vitro . Here, we demonstrate that mouse ESC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 459–470.
Published: 15 January 2013
... intensities of G1 (red fluorescence) and S/G2-M (green) that are associated with self-renewal and differentiation of single murine neural stem/progenitor cells (NSCs) and embryonic stem cells (ESCs). We further exploited these distinctive features using fluorescence-activated cell sorting to select...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3531–3542.
Published: 01 October 2012
... crucial roles in regulating embryonic angiogenesis and contribute to pathogenesis of atherosclerosis and the formation of arterial aneurysms ( Raines, 2000 ). Angiogenesis Embryonic stem cell Myocardin-related transcription factor B/MKL2 Mouse Transforming growth factor β © 2012...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2118–2129.
Published: 15 June 2012
... ) Competing interests statement The authors declare no competing financial interests. 28 3 2012 © 2012. Tcf3 Wnt signaling beta-catenin Embryonic stem cell Mouse embryogenesis The canonical Wnt signaling pathway is required for morphogenesis of many organs, and its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1525–1535.
Published: 15 April 2008
... ) 15 2 2008 © 2008. 2008 Bmp4 Embryonic stem cell Hemangioblast Hematopoiesis VEGF Mouse Upon differentiation, mouse embryonic stem (ES) cells can give rise to primitive and definitive hematopoietic precursors, an in vitro process that has been shown to recapitulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3827–3836.
Published: 01 November 2007
... into the uterine endometrium. However, Tead4 -/- embryos can produce embryonic stem cells, a derivative of ICM, and if the Tead4 allele is not disrupted until after implantation, then Tead4 -/- embryos complete development. Thus, Tead4 is the earliest gene shown to be uniquely required for specification...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2011–2022.
Published: 15 May 2006
.... 231 , 871 -880. Beddington, R. S. P. and Robertson, E. J. ( 1989 ). An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105 , 733 -737. Belting, H. G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried,S., Chitnis, A., Eschbach, C...
Journal Articles
Journal: Development
Development (2006) 133 (2): 209–216.
Published: 15 January 2006
...Ariel J. Levine; Ali H. Brivanlou The TGFβ superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily...
Includes: Supplementary data