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Keywords: Embryonic stem cell
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Journal Articles
Journal: Development
Development (2018) 145 (4): dev156836.
Published: 14 February 2018
... , T. , Hadjantonakis , A.-K. , Nowotschin , S. , Turner , D. A. and Martinez Arias , A. ( 2014 ). Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells . Development   141 , 4231 - 4242 . 10.1242/dev.113001 Wahl...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2016) 143 (9): 1571–1584.
Published: 1 May 2016
... characterized by loss of heterochromatin, activation of tandem repeats, oxidative stress and Rip3-associated necroptosis. In the human retina, BMI1 was preferentially expressed in cones at heterochromatic foci. BMI1 inactivation in human embryonic stem cells was compatible with retinal induction but impaired...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2015) 142 (20): 3488–3499.
Published: 15 October 2015
...Sophie M. Morgani; Joshua M. Brickman Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3113–3125.
Published: 15 September 2015
...Meritxell Huch; Bon-Kyoung Koo In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study tissue development, organogenesis and stem cell behavior ex vivo . When grown in a 3D environment, embryonic stem cells (ESCs) self-organize into organoids and acquire the right...
Journal Articles
Journal: Development
Development (2015) 142 (5): 846–857.
Published: 1 March 2015
...Guang Li; Karolina Plonowska; Rajarajan Kuppusamy; Anthony Sturzu; Sean M. Wu The transcriptional profiles of cardiac cells derived from murine embryos and from mouse embryonic stem cells (mESCs) have primarily been studied within a cell population. However, the characterization of gene expression...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2014) 141 (22): 4285–4297.
Published: 15 November 2014
..., as they all display a loss of posterior somites and PSM ( Fujimoto and Yanagisawa, 1979 ; Chapman and Papaioannou, 1998 ; Yoon et al., 2000 ; Yoon and Wold, 2000 ). However, gain-of-function studies on Tbx6 in mice ( Wehn and Chapman, 2010 ) and T in embryonic stem cells (ESCs) ( Lindsley et al., 2008 ) do...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (2): 459–470.
Published: 15 January 2013
... intensities of G1 (red fluorescence) and S/G2-M (green) that are associated with self-renewal and differentiation of single murine neural stem/progenitor cells (NSCs) and embryonic stem cells (ESCs). We further exploited these distinctive features using fluorescence-activated cell sorting to select...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (12): 2118–2129.
Published: 15 June 2012
... ) Competing interests statement The authors declare no competing financial interests. 28 3 2012 © 2012. Tcf3 Wnt signaling beta-catenin Embryonic stem cell Mouse embryogenesis The canonical Wnt signaling pathway is required for morphogenesis of many organs, and its...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (21): 3827–3836.
Published: 1 November 2007
... into the uterine endometrium. However, Tead4 -/- embryos can produce embryonic stem cells, a derivative of ICM, and if the Tead4 allele is not disrupted until after implantation, then Tead4 -/- embryos complete development. Thus, Tead4 is the earliest gene shown to be uniquely required for specification...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2011–2022.
Published: 15 May 2006
...-mail: josh.brickman@ed.ac.uk ) 3 3 2006 © 2006. 2006 Gastrulation Self-renewal Embryonic stem cell Lineage commitment Pou protein Pou5f1 Xenopus Germ layer specification involves an elaboration of intrinsic cell-autonomous factors and non-autonomous signalling...
Journal Articles
Journal: Development
Development (2006) 133 (2): 209–216.
Published: 15 January 2006
...Ariel J. Levine; Ali H. Brivanlou The TGFβ superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1998) 125 (4): 725–732.
Published: 15 February 1998
...Kyunghee Choi; Marion Kennedy; Alexander Kazarov; John C. Papadimitriou; Gordon Keller ABSTRACT Embryonic stem cell-derived embryoid bodies contain a unique precursor population which, in response to vascular endothelial growth factor, gives rise to blast colonies in semi-solid medium. Upon...
Journal Articles
Journal: Development
Development (1993) 119 (4): 1093–1105.
Published: 1 December 1993
...Joy T. Yang; Helen Rayburn; Richard O. Hynes ABSTRACT A loss of function mutation of the murineα 5 integrin gene generated by gene targeting in embryonic stem cells is a recessive embryonic lethal. The mutant embryos start to show observable defects by day 9 of gestation and die around day 10-11...