... heavily on the spatiotemporal recruitment of the endothelial cells to the embryonic pancreas. Although it is known that VEGFA secreted by the epithelium recruits the endothelial cells to the specific domains within the developing pancreas, the mechanism that controls the timing of such recruitment...

... the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis...

... of regulation reinforce patterning. Here, we demonstrate that geometrical confinement orchestrates the spatial organisation of initially randomly positioned subpopulations of spontaneously differentiating mouse embryonic stem cells. We use micropatterning in combination with pharmacological manipulations...

... ablation or following indomethacin-induced injury. These highly proliferative reactive adult Trop2 + cells exhibited a transcriptome displaying similarity with that of gastric embryonic Trop2 + cells, suggesting that epithelium regeneration in adult stomach glands involves the partial re-expression...

.../Protocols/protocols.htm . Table 3. Phenotypic analysis of validated target genes ORF Gene Identification Published RNAi * Embryonic lethality (n) Embryonic function Larval phenotype C28C12.7 spp-10 Predicted prosaposin Wild type 1% (787) R02D3.1 Dehydrogenase...

...Eric C. Liao; Nikolaus S. Trede; David Ransom; Augustin Zapata; Mark Kieran; Leonard I. Zon Vertebrate hematopoiesis occurs in two distinct phases, primitive (embryonic) and definitive (adult). Genes that are required specifically for the definitive program, or for both phases of hematopoiesis...

...Karolina Piotrowska; Florence Wianny; Roger A. Pedersen; Magdalena Zernicka-Goetz Two independent studies have recently suggested similar models in which the embryonic and abembryonic parts of the mouse blastocyst become separated already by the first cleavage division. However, no lineage tracing...

... in a 231 and 375 bp fragment for the wild type and targeted allele, respectively ( Fig. 1D ). β-galactosidase activity was determined in embryonic materials, as described ( Marin et al., 1997 ; Hogan et al., 1994 ), with fixation time varying from 1 minute for cells, embryoid bodies, blastocysts...

... GATA Embryonic Lethality Extraembryonic Endoderm Mouse The GATA zinc finger transcription factors play a crucial role in the development and differentiation of a number of tissues. These factors bind the basic consensus sequence A/TGATA/G through a conserved Cys-X 2 -Cys-X 17 -Cys-X 2 -Cys...

...Neil Kabrun; Hans-Jörg Bühring; Kyunghee Choi; Axel Ullrich; Werner Risau; Gordon Keller Summary We have investigated the expression pattern of the Flk-1 receptor tyrosine kinase in mouse embryonic and fetal hematopoietic tissues as well as on hematopoietic precursor cells derived from...