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Keywords: Eiger
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Journal Articles

JAK/STAT signalling mediates cell survival in response to tissue stress

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Marco La Fortezza, Madlin Schenk, Andrea Cosolo, Addie Kolybaba, Isabelle Grass, Anne-Kathrin Classen
Journal: Development
Development (2016) 143 (16): 2907–2919.
https://doi.org/10.1242/dev.132340
Published: 15 August 2016
... damage, JAK/STAT signalling and its effector Zfh2 promote the survival of JNK-signalling cells in Drosophila imaginal discs, thereby limiting tissue damage and facilitating systemic responses. JAK/STAT JNK Cell survival Compensatory proliferation Cancer Injury-induced apoptosis Eiger Cell...
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Includes: Supplementary data
Journal Articles

Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth

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Chiswili Chabu, Tian Xu
Journal: Development
Development (2014) 141 (24): 4729–4739.
https://doi.org/10.1242/dev.108092
Published: 15 December 2014
... and promotes the export of the pro-apoptotic ligand Eiger ( Drosophila TNF). This blocks tumor cell death and stimulates overgrowth by activating the JNK-JAK-STAT non-autonomous proliferation signal from the neighboring wild-type cells. Inhibition of Eiger/TNF exocytosis or interfering with the JNK-JAK-STAT...
View articletitled, Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
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Includes: Supplementary data