... ommatidium patterning requires the epidermal growth factor receptor (EGFR) signalling pathway, which transcriptionally governs rok - and Drak -dependent AJ remodelling while also promoting neurogenesis. In conclusion, our work reveals an important role for Drak in regulating AJ remodelling during retinal...

..., Spain 31 1 2007 © 2007. 2007 Iroquois complex Imaginal wing disc Drosophila Notum development Dpp signalling EGFR signalling Drosophila imaginal discs provide an excellent model system to investigate how genetic information specifies the different body regions...

... preventing tubule hyperplasia. Cell division Malpighian tubules Proneural genes EGFR signalling seven up wingless Drosophila While our understanding of cell cycle regulation at the molecular level is detailed and sophisticated, our knowledge of the way in which cell division...

... composed of vein-like tissue. Egfr signalling and net exert mutually antagonising activities during the specification of vein versus intervein fate. While Egfr signalling represses net transcription, net exhibits a two-tiered control by repressing rho transcription and interfering with Egfr signalling...

... of the requirement for grk mRNA localization in Egfr signalling would be to specifically mislocalize grk mRNA in stage 3-6 oocytes. To reach this goal, further studies of grk mRNA are necessary to delineate the elements within the transcript that mediate posterior localization in stages 3-6. mRNA...

... show that EGFR signalling specifies the anterior denticles in each segment of the larval abdomen. We provide evidence that these denticles derive from a segmental zone of embryonic cells in which EGFR signalling activity is maximal. Within each segment, there is a competition between the denticle fate...