... also function more broadly in development and disease. In the absence of EDA-A1/EDAR/NF-κB signaling, WNT/β-catenin initiates HF placode formation in a messy pre-pattern up to the pre-placode stage (hair morphogenesis stage 0/1; Paus et al., 1999 ) in which a subset of placode markers is already...

... , 73 – 84 . Charles C. , Pantalacci S. , Tafforeau P. , Headon D. , Laudet V. , Viriot L. ( 2009 ). Distinct impacts of Eda and Edar loss of function on the mouse dentition . PLoS ONE 4 , e4985 . Colosimo P. F. , Hosemann K. E. , Balabhadra S...

... appendages, functions in developing SMG. Surprisingly and unlike in developing hair follicles and teeth, canonical Wnt signaling activity did not colocalize with Edar/NF-κB in salivary gland epithelium. Instead, we observed high mesenchymal Wnt activity and show that ablation of mesenchymal Wnt signaling...

... IκBαΔN ). However, the developmental processes regulated by NF-κB in hair follicles has remained unknown. Furthermore, the similarity between the phenotypes of c IκBAΔN mice and mice deficient in Eda A1( tabby ) or its receptor EdaR ( downless ) raised the issue of whether in vivo NF-κB regulates...

...Leslie Houghton; Catherine Lindon; Bruce A. Morgan The ectodysplasin pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role in epidermal organ formation in mammals. Mutations in the genes encoding these proteins...

... ectodermal organs, including hair, teeth and exocrine glands. The recent cloning of the genes that underlie these syndromes, ectodysplasin ( ED1 ) and the ectodysplasin A receptor ( EDAR ), and their identification as a novel TNF ligand-receptor pair suggested a role for TNF signaling in embryonic...

... identified. downless ( Dl ) encodes Edar, a novel member of the tumour necrosis factor (TNF) receptor family, containing the characteristic extracellular cysteine rich fold, a single transmembrane region and a death homology domain close to the C terminus. tabby ( Ta ) encodes ectodysplasin-A (Eda) a type II...