...Atsuko Yamazaki; Yoshiaki Morino; Makoto Urata; Masaaki Yamaguchi; Takuya Minokawa; Ryohei Furukawa; Mariko Kondo; Hiroshi Wada ABSTRACT In several model animals, the earliest phases of embryogenesis are regulated by lineage-specific genes, such as Drosophila bicoid . Sea urchin (echinoid...

...Li-Hsun Chang; Peilong Chen; Mong-Ting Lien; Yu-Huei Ho; Chiao-Ming Lin; Yi-Ting Pan; Shu-Yi Wei; Jui-Chou Hsu Cell sorting involves the segregation of two cell populations into `immiscible' adjacent tissues with smooth borders. Echinoid (Ed), a nectin ortholog, is an adherens junction protein...

... Drosophila eye development, differentiated photoreceptors form clusters that rotate independently of the surrounding interommatidial cells (ICs). Here, we demonstrate that both Echinoid (Ed), an adherens junction-associated cell adhesion molecule, and Flamingo (Fmi), a PCP determinant, are endocytosed via...

...Caroline Laplante; Laura A. Nilson Epithelial morphogenesis requires cell movements and cell shape changes coordinated by modulation of the actin cytoskeleton. We identify a role for Echinoid (Ed), an immunoglobulin domain-containing cell-adhesion molecule, in the generation of a contractile...

... of genes of the Notch signaling pathway results in a neurogenic phenotype: hyperplasia of the nervous system accompanied by a parallel loss of epidermis. Echinoid (Ed), a cell membrane associated Immunoglobulin C2-type protein, has previously been shown to be a negative regulator of the EGFR pathway during...

...Luis M. Escudero; Shu-Yi Wei; Wei-Hsin Chiu; Juan Modolell; Jui-Chou Hsu echinoid ( ed ) encodes an immunoglobulin domain-containing cell adhesion molecule that negatively regulates the Egfr signaling pathway during Drosophila photoreceptor development. We show a novel function of Ed, i.e...

...Susan A. Spencer; Ross L. Cagan Precisely regulated Egfr activity is essential for normal development and cell differentiation. We demonstrate that the transmembrane protein Echinoid is required to downregulate Egfr activity in the developing Drosophila eye, ensuring a normal array of R8...

...Rafique Islam; Shu-Yi Wei; Wei-Hsin Chiu; Michael Hortsch; Jui-Chou Hsu echinoid ( ed ) encodes an cell-adhesion molecule (CAM)that contains immunoglobulin domains and regulates the EGFR signaling pathway during Drosophila eye development. Based on our previous genetic mosaic and epistatic analysis...

...Jia-Min Bai; Wei-Hsin Chiu; Jiunn-Chin Wang; Ting-Hue Tzeng; Norbert Perrimon; Jui-Chou Hsu ABSTRACT Photoreceptor and cone cells in the Drosophila eye are recruited following activation of the epidermal growth factor receptor (EGFR) pathway. We have identified echinoid ( ed ) as a novel putative...