... molecules as regulators of haemocyte recruitment to SHCs. We show that larval haemocytes express ninjurins, which are required for targeting haemocytes to SHCs. However, at pupariation, ecdysteroid signalling stimulates Ab expression, which collaborates with TFs, including Blimp-1 and Hr3, to repress...

... expression pattern and is most similar in sequence to vertebrate Npc2. Mutation of npc2a results in abnormal sterol distribution in many cells, as in Drosophila npc1a or mammalian NPC mutant cells. In contrast to the ecdysteroid-deficient, larval-lethal phenotype of npc1a mutants, npc2a mutants are viable...

...Tatiana Kozlova; Carl S. Thummel Ecdysteroid signaling in insects is transduced by a heterodimer of the EcR and USP nuclear receptors. In order to monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic animals that express a fusion of the GAL4 DNA...

... that cells throughout the optic anlage contain NOS and produce NO. Signaling via NO inhibits proliferation in the anlage. When exposed to low levels of ecdysteroid, NO production is stimulated and proliferation ceases. When steroid levels are increased, NO production begins to decrease within 15 minutes...

...David T. Champlin; James W. Truman ABSTRACT The eye primordium of the moth, Manduca sexta , shows two different developmental responses to ecdysteroids depending on the concentration to which it is exposed. Tonic exposure to moderate levels of 20-hydroxyecdysone (20E) or its precursor, ecdysone...

...David T. Champlin; James W. Truman ABSTRACT Cell proliferation within the optic lobe anlagen is dependent on ecdysteroids during metamorphosis of the moth Manduca sexta . We use cultured tissues to show that ecdysteroids must be maintained above a sharp threshold concentration to sustain...

... case. One prerequisite for this death is the decline of ecdysteroids at the end of metamorphosis. Treatment of flies with 20hydroxyecdysone blocks the death of the cells, but only if given at least 3 hours before the normal time of degeneration. The correlation of a unique pattern of receptor isoform...

... determination ecdysteroid Drosophila The three genes coding for the yolk polypeptides (YPs) in Drosophila melanogaster ( Bownes & Hames, 1977 ; Barnett, Paehl, Gergen & Wensink, 1980 ) are transcribed in the adult female fat body and ovarian follicle cells ( Bownes & Hames, 1978...