... TGFβ Signal transduction Ecdysone receptor During embryonic development in animals, secreted Transforming Growth Factor β (TGFβ) proteins perform a multitude of tasks. Later in life, mutations that disrupt TGFβ signaling often lead to tumor growth. One group of TGFβ pathway regulators...

... integrases . Proc. Natl. Acad. Sci. USA 104 , 3312 – 3317 . Cakouros D. , Daish T. J. , Kumar S. ( 2004 ). Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues . J. Cell Biol. 165 , 631 – 640...

... hours AL3E on sucrose alone produced wing discs with precocious WG, CT and SENS expression. In addition,knocking down the Ecdysone receptor (EcR) selectively in the discs also promoted premature WG, CUT and SENS expression in the wing discs of sucrose-fed pre-critical weight larvae. EcR is involved...

... that these larval neurons are eliminated via a caspase-dependent pathway. Genetic and transgenic disruptions of ecdysone signal transduction involving ecdysone receptor-B (EcR-B) isoforms suppressed vCrz death, whereas transgenic re-introduction of either EcR-B1 or EcR-B2 isoform into the EcR-B -null mutant resumed...

... of neuronal remodeling and suggest that functional ecdysone receptor is necessary for some, but not all, remodeling events. * Author for correspondence (e-mail: [email protected] ) 31 10 2005 © 2006. 2006 Drosophila Axon remodeling Ecdysone receptor Metamorphosis...

...Margrit Schubiger; Clément Carré; Christophe Antoniewski; James W. Truman Loss of function of either the ecdysone receptor (EcR) or Ultraspiracle(USP), the two components of the ecdysone receptor, causes precocious differentiation of the sensory neurons on the wing of Drosophila . We propose...

... at the onset of metamorphosis. * Author for correspondence (e-mail: [email protected] ) 19 04 1999 13 06 1999 © 2000 by Company of Biologists 2000 Drosophila Ecdysone ecdysone receptor ultraspiracle Molting Metamorphosis Imaginal disc During Drosophila...

...Margrit Schubiger; James W. Truman ABSTRACT The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP). Analysis of usp mutant clones in the wing disc...

.... These observations indicate that usp is required for ecdysone receptor activity in vivo, demonstrate that the EcR/USP heterodimer functions in a stage-specific manner during the onset of metamorphosis and implicate a role for usp in the decision to molt or pupariate in response to ecdysone pulses during larval...

..., cell death and the remodeling of larval neurons into their adult forms. In Drosophila , expression of specific ecdysone receptor (EcR) isoforms has been correlated with particular responses, suggesting that different EcR isoforms may govern distinct steroid-induced responses in these cells. We have...

...James W. Truman; William S. Talbot; Susan E. Fahrbach; David S. Hogness ABSTRACT In insects, the ecdysteroids act to transform the CNS from its larval to its adult form. A key gene in this response is the ecdysone receptor ( EcR ), which has been shown in Drosophila to code for 3 protein isoforms...