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Keywords: Ecdysone
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Journal: Development
Development (2024) 151 (12): dev202828.
Published: 17 June 2024
... require the hormone ecdysone (Ec) for growth but require a drop in circulating Ec levels to regenerate. Examining Ec dynamics more closely, we find that transcriptional activity of the Ec-receptor (EcR) drops in uninjured regions of wing discs, but simultaneously rises in cells around the injury-induced...
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Journal Articles
Journal: Development
Development (2024) 151 (11): dev202542.
Published: 4 June 2024
... the niche. We find that GSC abscission failure is caused by increased Ecdysone hormone signaling induced upon mating, which leads to disrupted somatic encystment of the germline. Abscission failure is rescued by isolating males from females, but recurs with resumption of mating. Importantly, reiterative...
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev190066.
Published: 27 November 2020
... replacement ( Tettamanti and Casartelli, 2019 ). Intensive studies based on the larva-pupa transition of D . melanogaster have demonstrated the determinant role of ecdysone signaling in PCD processes that affect the salivary glands, midgut and fat body. Ecdysone, or rather its most bioactive derivative 20...
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Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila National Institutes of Health T32GM007092 National Science Foundation 10.13039/100000001 DGE-1650116...
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Journal Articles
Journal: Development
Development (2019) 146 (24): dev182568.
Published: 20 December 2019
...Coralie Drelon; Michael F. Rogers; Helen M. Belalcazar; Julie Secombe ABSTRACT In Drosophila , the larval prothoracic gland integrates nutritional status with developmental signals to regulate growth and maturation through the secretion of the steroid hormone ecdysone. While the nutritional signals...
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Neural development
Journal: Development
Development (2019) 146 (8): dev163592.
Published: 17 April 2019
... to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved...
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Journal Articles
Journal: Development
Development (2018) 145 (21): dev165654.
Published: 2 November 2018
... studies. Of note, even among these studies, there are considerable differences in the reported phenotypes between groups and publications ( Grönke et al., 2010 ; Ikeya et al., 2002 ; Rulifson et al., 2002 ; Zhang et al., 2009 ). To further define the role of ecdysone signalling in IPCs, we first...
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Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (6): dev159699.
Published: 14 March 2018
... by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting...
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Journal Articles
Journal: Development
Development (2018) 145 (2): dev154534.
Published: 25 January 2018
... in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell...
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Journal Articles
Journal: Development
Development (2017) 144 (23): 4406–4421.
Published: 1 December 2017
...-licence-1-1/ Summary: Identification of a requirement for 20-hydroxyecdysone in tissue patterning leads to the discovery that dynamic cell rearrangements and shape changes contribute to oriented tissue growth in the Drosophila wing disc. Ecdysone Insulin Culture Imaginal disc...
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Journal Articles
Journal: Development
Development (2016) 143 (19): 3591–3603.
Published: 1 October 2016
... - with multiple cis -regulatory elements integrating nutritional and tissue-specific inputs. dFOXO Ecdysone Insulin receptor Retinoblastoma Transcriptional enhancer National Institutes of Health 10.13039/100000002 GM056976 The insulin signaling pathway plays essential roles...
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Journal Articles
Journal: Development
Development (2016) 143 (13): 2410–2416.
Published: 1 July 2016
... timing is believed to be determined by the release of a steroid hormone, ecdysone (E), from the prothoracic gland. Here, we demonstrate that the ecdysone-20-monooxygenase Shade determines pupation timing by converting E to 20-hydroxyecdysone (20E) in the fat body, which is the organ that senses...
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Journal Articles
Journal: Development
Development (2015) 142 (21): 3758–3768.
Published: 1 November 2015
... LC-MS/MS Dietary sterols Ecdysone Ecdysteroids Makisterone A Drosophila melanogaster is emerging as a powerful model in which to study hormonal control of growth, metabolism and development (reviewed by Padmanabha and Baker, 2014 ; Shim et al., 2013 ; Tennessen and Thummel, 2011...
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Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 1 March 2015
... and germ cell differentiation, and promotes the accumulation of Broad-Z1, which is also a target of the steroid hormone ecdysone. Epistasis analysis shows that Activin controls cell proliferation in an ecdysone-independent manner and TF differentiation by affecting ecdysone targets. We propose...
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Journal Articles
Journal: Development
Development (2014) 141 (20): 3955–3965.
Published: 15 October 2014
... to fine-tune the dynamics of hormone production. In Drosophila , transient increases of the steroid prohormone ecdysone, produced at each larval stage, are necessary to trigger moulting and metamorphosis. Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4730–4739.
Published: 1 December 2013
... coordinate growth and timing of maturation during development, the mechanisms generating these pulses are not known. Here we show that the ecdysone steroid pulse that drives the juvenile-adult transition in Drosophila is determined by feedback circuits in the prothoracic gland (PG), the major steroid...
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Journal Articles
Journal: Development
Development (2011) 138 (13): 2693–2703.
Published: 1 July 2011
... that activin signaling regulates competence of the prothoracic gland to receive PTTH and insulin signals, and that these two pathways act at the mRNA and post-transcriptional levels, respectively, to control ecdysone biosynthetic enzyme expression. This dual regulatory circuitry may provide a cross-check...
Includes: Supplementary data