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Keywords: Earmuff
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Journal Articles

The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors

Yonggang Xie, Xiaosu Li, Xiaobing Deng, Yanjun Hou, Krysten O'Hara, Andreacarola Urso, Ying Peng, Li Chen, Sijun Zhu
Journal: Development
Development (2016) 143 (17): 3109–3118.
https://doi.org/10.1242/dev.137281
Published: 1 September 2016
... and the elimination of INPs. The elimination of INPs results from the premature differentiation of INPs due to ectopic Prospero expression in newly generated immature INPs (imINPs), whereas the increase in type II neuroblasts results from the dedifferentiation of imINPs due to loss of Earmuff at later stages of imINP...
View articletitled, The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors
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Includes: Supplementary data
Journal Articles

Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff

Xiaosu Li, Yonggang Xie, Sijun Zhu
Journal: Development
Development (2016) 143 (14): 2511–2521.
https://doi.org/10.1242/dev.136184
Published: 15 July 2016
..., the Drosophila NSCs) and transforms type II NBs into type I NBs. Here, we demonstrate that Notch maintains type II NBs by suppressing the activation of earmuff ( erm ) by Pointed P1 (PntP1). We show that loss of Notch or components of its canonical pathway leads to PntP1-dependent ectopic Erm expression in type...
View articletitled, Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff
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Includes: Supplementary data
Journal Articles

Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors

Derek H. Janssens, Hideyuki Komori, Daniel Grbac, Keng Chen, Chwee Tat Koe, Hongyan Wang, Cheng-Yu Lee
Journal: Development
Development (2014) 141 (5): 1036–1046.
https://doi.org/10.1242/dev.106534
Published: 1 March 2014
... restrict the developmental potential of intermediate progenitor cells. Here, we report that the transcriptional repressor protein Earmuff (Erm) functions temporally after Brain tumor (Brat) and Numb to restrict the developmental potential of uncommitted (immature) INPs. Consistently, endogenous Erm...
View articletitled, Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors
Open the PDF for Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors in another window
Includes: Supplementary data