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1-15 of 15
Keywords: Ear
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Journal Articles
Journal:
Development
Development (2011) 138 (17): 3689–3698.
Published: 1 September 2011
...Paola Betancur; Tatjana Sauka-Spengler; Marianne Bronner The otic placode, a specialized region of ectoderm, gives rise to components of the inner ear and shares many characteristics with the neural crest, including expression of the key transcription factor Sox10. Here, we show that in avian...
Includes: Supplementary data
Journal Articles
Yaopan Mao, Joanna Mulvaney, Sana Zakaria, Tian Yu, Katherine Malanga Morgan, Steve Allen, M. Albert Basson, Philippa Francis-West, Kenneth D. Irvine
Journal:
Development
Development (2011) 138 (5): 947–957.
Published: 1 March 2011
... in a murine Dachsous homolog, Dchs1 . Analysis of the phenotypes of Dchs1 mutant mice and comparisons with Fat4 mutant mice identify requirements for these genes in multiple organs, including the ear, kidney, skeleton, intestine, heart and lung. Dchs1 and Fat4 single mutants and Dchs1 Fat4 double mutants have...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2009) 136 (16): 2837–2848.
Published: 15 August 2009
...Leila Abbas; Tanya T. Whitfield Endolymph is the specialised extracellular fluid present inside the inner ear. In mammals, disruptions to endolymph homeostasis can result in either collapse or distension of the endolymphatic compartment in the cochlea, with concomitant hearing loss. The zebrafish...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Development
Development (2006) 133 (7): 1277–1286.
Published: 1 April 2006
...Rachael Brooker; Katsuto Hozumi; Julian Lewis Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and supporting cells. Notch signalling is thought to govern this pattern of differentiation through lateral inhibition. Recent experiments in the chick suggest...
Includes: Supplementary data
Journal Articles
Zebrafish foxi1 mediates otic placode formation and jaw development
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Journal:
Development
Development (2003) 130 (5): 929–940.
Published: 1 March 2003
...Keely S. Solomon; Tetsuhiro Kudoh; Igor B. Dawid; Andreas Fritz The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within...
Journal Articles
Developmental functions of the Distal-less /Dlx homeobox genes
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Journal:
Development
Development (2002) 129 (19): 4371–4386.
Published: 1 October 2002
... ; Zerucha et al., 2000 ). The intergenic regions of mouse Dlx1 and Dlx2 and Dlx3 and Dlx4 (previously Dlx7 ) also appear to contain shared cis elements (M. Ekker, personal communication) ( Sumiyama et al., 2002 ). During zebrafish ear development, dlx3b (previously dlx3 ) is required...
Journal Articles
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development
Available to Purchase
Journal:
Development
Development (2000) 127 (17): 3703–3713.
Published: 1 September 2000
... under the control of the Pax2 locus. Midbrain and cerebellum development was entirely rescued in Pax25ki/5ki embryos. Pax5 could furthermore completely substitute for the Pax2 function during morphogenesis of the inner ear and genital tracts, despite the fact that the Pax5 transcript of the Pax25ki...
Journal Articles
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
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Journal:
Development
Development (2000) 127 (6): 1185–1196.
Published: 15 March 2000
.... ( 1999 ). Math1: An essential gene for the generation of inner ear hair cells . Science 284 , 1837 – 1841 . 10.1126/science.284.5421.1837 Black , B. L. , Molkentin , J. D. and Olson , E. N. ( 1998 ). Multiple roles for the MyoD basic region in transmission...
Journal Articles
Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant
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Journal:
Development
Development (1998) 125 (23): 4637–4644.
Published: 1 December 1998
...Catherine Haddon; Yun-Jin Jiang; Lucy Smithers; Julian Lewis ABSTRACT Mechanosensory hair cells in the sensory patches of the vertebrate ear are interspersed among supporting cells, forming a fine-grained pattern of alternating cell types. Analogies with Drosophila mechanosensory bristle...
Journal Articles
Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development
Available to PurchaseJulie Adam, Anna Myat, Isabelle Le Roux, Mark Eddison, Domingos Henrique, David Ish-Horowicz, Julian Lewis
Journal:
Development
Development (1998) 125 (23): 4645–4654.
Published: 1 December 1998
...Julie Adam; Anna Myat; Isabelle Le Roux; Mark Eddison; Domingos Henrique; David Ish-Horowicz; Julian Lewis ABSTRACT The sensory patches in the vertebrate inner ear are similar in function to the mechanosensory bristles of a fly, and consist of a similar set of cell types. If they are truly...
Journal Articles
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2 . 1 ( noi ) function
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Journal:
Development
Development (1998) 125 (16): 3063–3074.
Published: 15 August 1998
... and spinal cord ( Fig. 4C,D ; data not shown). Later in embryogenesis, the two Pax2 genes are similarly transcribed in the common expression domains, except in the developing ear where their relative mRNA levels vastly differ ( Fig. 4 ). While the Pax2 . 1 gene is expressed in the otic placode (10...
Journal Articles
Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
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Journal:
Development
Development (1998) 125 (6): 1113–1122.
Published: 15 March 1998
... and spinal cord. Later expression of HrPax-258 in atrial primordia implies that basal chordates such as ascidians have already acquired a sensory organ that develops from epidermal thickenings (placodes) and expresses HrPax-258 ; we suggest it is homologous to the vertebrate ear. Therefore, placodes...
Journal Articles
Mutations affecting development of the zebrafish ear
Available to PurchaseIn collection:
The zebrafish issue: 25 years on
Jarema Malicki, Alexander F. Schier, Lilianna Solnica-Krezel, Derek L. Stemple, Stephan C. F. Neuhauss, Didier Y. R. Stainier, Salim Abdelilah, Zehava Rangini, Fried Zwartkruis, Wolfgang Driever
Journal:
Development
Development (1996) 123 (1): 275–283.
Published: 1 December 1996
... affecting several aspects of ear development, including: specification of the otic placode, growth of the otic vesicle (otocyst), otolith formation, morphogenesis of the semicircular canals and differentiation of the otic capsule. Here we report initial phenotypic and genetic characterization of 20...
Journal Articles
Development of the mammalian ear: coordinate regulation of formation of the tympanic ring and the external acoustic meatus
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Journal:
Development
Development (1996) 122 (1): 173–179.
Published: 1 January 1996
... external acoustic meatus retinoic acid mouse ear The formation of the mammalian ear has been the object of intense study since the early nineteenth century, and some of the most striking characteristics distinguishing the mammalian skull from that of other vertebrates are seen in the structure...
Journal Articles
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
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Journal:
Development
Development (1993) 117 (2): 769–778.
Published: 1 February 1993
... fields, and possibly lineage compart-ments, during organogenesis stages of mouse develop-ment. 19 10 1992 © 1993 by Company of Biologists 1993 goosecoid gene expression branchial arches tongue ear mandible limb buds Work on Drosophila and vertebrate embryos has shown...