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Keywords: EMT
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev197525.
Published: 10 May 2021
...Xin Sun; Sophia Malandraki-Miller; Tahnee Kennedy; Elad Bassat; Konstantinos Klaourakis; Jia Zhao; Elisabetta Gamen; Joaquim Miguel Vieira; Eldad Tzahor; Paul R. Riley ABSTRACT During heart development, epicardial cells residing within the outer layer undergo epithelial-mesenchymal transition (EMT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev198036.
Published: 20 April 2021
...Guojun Sheng ABSTRACT Over 50 years after its discovery in early chick embryos, the concept of epithelial-mesenchymal transition (EMT) is now widely applied to morphogenetic studies in both physiological and pathological contexts. Indeed, the EMT field has witnessed exponential growth in recent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
... and experimental demonstration of the physiological relevance of such activities are rare. Here, we have used chick neural crest (NC) cells, a highly migratory stem cell population likened to invasive cancer cells, as a model for physiological epithelial-mesenchymal transition (EMT). We demonstrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184960.
Published: 03 February 2020
... the epiblast generates mesoderm and endoderm germ layers through epithelial-mesenchymal transition (EMT). Although gastrulation EMT coincides with loss of epiblast pluripotency, pluripotent cells in development and in vitro can adopt either mesenchymal or epithelial morphology. The relationship...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev171017.
Published: 11 April 2019
... epigenetic miRNA-gene regulatory circuit, conserved in cancer, that controls the timing of neural crest epithelial-to-mesenchymal transition. EMT Neural crest miR-203 Snail2 DNA methylation Phf12 Migration Whole-mount chick immunohistochemistry was performed as described previously...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
... primitive streak (PS) by WNT. In the pluripotent state, E-cadherin (E-CAD) transduces boundary forces to focus WNT signaling to the colony border. Following application of WNT ligand, E-CAD mediates a front or wave of epithelial-to-mesenchymal (EMT) conversion analogous to PS extension in an embryo. By...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev157628.
Published: 01 March 2018
... to remove the epithelial layers. We observed morphological changes in the seam epithelia, intermingling of cells of epithelial descent into the mesenchyme and molecular signatures of epithelial-mesenchymal transition (EMT). Utilizing mouse lines with cephalic epithelium-specific Pbx loss exhibiting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3440–3453.
Published: 01 October 2017
... to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1 , snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2456–2468.
Published: 01 July 2017
...-cadherins during epithelial-to-mesenchymal transition (EMT). However, the mechanism that controls the upregulation of N-cadherin remains unknown. Here, we show that platelet-derived growth factor receptor alpha (PDGFRα) and its ligand platelet-derived growth factor A (PDGF-A) are co-expressed in migrating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1412–1424.
Published: 15 April 2017
... cells to a PM fate. FGF-mediated PM induction in NMPs functions in tight coordination with canonical Wnt signaling during the epithelial to mesenchymal transition (EMT) from NMP to mesodermal progenitor. Wnt signaling initiates EMT, whereas FGF signaling terminates this event. Our results indicate that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 649–656.
Published: 15 February 2017
...Hervé Acloque; Oscar H. Ocaña; Diana Abad; Claudio D. Stern; M. Angela Nieto Snail and Zeb transcription factors induce epithelial-to-mesenchymal transition (EMT) in embryonic and adult tissues by direct repression of E-cadherin transcription. The repression of E-cadherin transcription by the EMT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4291–4300.
Published: 01 December 2016
... examples of EMT and collective migration and describe how they fit into the shared framework we propose for migration. Of note, we focus on what is known regarding cell behaviours, properties and interactions prior to and during migration, rather than on the factors triggering migration and establishing...
Journal Articles
Journal: Development
Development (2016) 143 (6): 1041–1054.
Published: 15 March 2016
... endocardial-to-mesenchymal transformation (EMT) through postnatal steps of valvulogenesis. However, genetic redundancy and lethality have made it challenging to define specific roles of the canonical Wnt pathway at different stages of valve formation. We developed a transgenic mouse system that provides...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1516–1527.
Published: 15 April 2015
...-mesenchymal transition (EMT) are important for A-P axis elongation in vertebrate embryos. The evolutionarily conserved planar cell polarity (PCP) pathway regulates CE, and Wnts regulate many aspects of gastrulation including CE and EMT. However, the Wnt ligands that regulate A-P axis elongation in mammalian...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4279–4284.
Published: 15 November 2014
...@mail.med.upenn.edu ) Competing interests The authors declare no competing financial interests. 29 4 2014 5 9 2014 © 2014. Published by The Company of Biologists Ltd 2014 Caenorhabditis elegans EMT Delamination Epithelia Junction Ras We thank David Hall and the Center...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4285–4297.
Published: 15 November 2014
... 2014 © 2014. Published by The Company of Biologists Ltd 2014 bHLH transcription factor Paraxial mesoderm PSM Differentiation EMT Motility Wnt Embryonic stem cell Somite Mouse The process of vertebrate body formation provides an excellent opportunity to understand the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (12): 2506–2515.
Published: 15 June 2014
...Matthew R. Clay; Mary C. Halloran The epithelial-to-mesenchymal transition (EMT) is a complex change in cell phenotype that is important for cell migration, morphogenesis and carcinoma metastasis. Loss of epithelial cell adhesion and tight regulation of cadherin adhesion proteins are crucial for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3198–3209.
Published: 01 August 2013
...Matthew R. Clay; Mary C. Halloran Epithelial-to-mesenchymal transitions (EMTs) are crucial for morphogenesis and carcinoma metastasis, yet mechanisms controlling the underlying cell behaviors are poorly understood. RhoGTPase signaling has been implicated in EMT; however, previous studies have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 3973–3985.
Published: 01 November 2012
... ). ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas . Oncogene ( in press ). DeLaughter D. M. , Saint-Jean L. , Baldwin H. S. , Barnett J. V. ( 2011 ). What chick and mouse models have taught us about the role of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2040–2049.
Published: 01 June 2012
... transition (EMT). Although several signaling pathways have been identified that disrupt EMT, no pathway has been reported that restricts this developmental process. Here, we identify neurofibromin 1 (Nf1) as a key mediator of epicardial EMT. To determine the function of Nf1 during epicardial EMT and the...
Includes: Supplementary data