..., these findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism. SUMMARY : The AAA ATPase Vps4 is required for and promotes EGFR activity during Drosophila eye development, acting via an endocytosis-independent mechanism. Vps4 Endocytosis EGF receptor...

... primordium, which extensively proliferates during larval development to give rise to the dorsal thoracic body wall and the adult wing. The developmental decision between wing and body wall is defined by the opposing activities of two secreted signalling molecules, Wingless and the EGF receptor ligand Vein...

... ) * Present address: Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA † Present address: Department of Genomic Sciences, University of Washington,Seattle, WA 98195, USA 30 12 2003 © 2004. 2004 EGF receptor Denticle belt...

... for correspondence (e-mail: [email protected] and [email protected] ) * These authors contributed equally to this work 9 9 2003 © The Company of Biologists Limited 2003 2003 echinoid Notch EGF receptor Cell adhesion Signaling Bristle patterning The dorsal mesothorax...

...Emma L. Rawlins; Neil M. White; Andrew P. Jarman EGF receptor signalling plays diverse inductive roles during development. To achieve this, its activity must be carefully regulated in a variety of ways to control the time, pattern, intensity and duration of signalling. We show that the cell surface...

.... Together,our results suggest a model in which Nrg acts as a heterophilic ligand and activator of Ed, which in turn antagonizes EGFR signaling. † Authors for correspondence (e-mail: [email protected] and [email protected] ) 23 1 2003 © 2003. 2003 EGF receptor Cell adhesion...

... system. In the eye, the EGF receptor, Notch, and intact primary pigment and cone cells have been implicated in survival or death signals. An antibody raised against a peptide from human caspase 3 was used to investigate how extracellular signals controlled spatial patterning of cell death. The antibody...

... cell migration to form an elaborate branched network essential for oxygen delivery throughout the larva. FGF signaling is required for guided migration of all tracheal branches, whereas the DPP, EGF receptor, and Wingless/WNT signaling pathways each mediate the formation of specific subsets of branches...

...Lihui Yang; Nicholas E. Baker ABSTRACT The Drosophila EGF receptor is required for differentiation of many cell types during eye development. We have used mosaic analysis with definitive null mutations to analyze the effects of complete absence of EGFR, Ras or Raf proteins during eye development...

...Philip R. Elstob; Véronique Brodu; Alex P. Gould ABSTRACT Signaling from the EGF receptor (EGFR) can trigger the differentiation of a wide variety of cell types in many animal species. We have explored the mechanisms that generate this diversity using the Drosophila peripheral nervous system...

.... Flies of ed mutant produce extra photoreceptor and cone cells. Conversely, ectopic overexpression of ed in the eye leads to reduction of photoreceptor number. We demonstrate that ED acts by converging on TTK88, the most downstream component known in EGF receptor signaling. Our results not only...

... , R. J. and Schüpbach , T. ( 1989 ). Coordinately and differentially mutable activities of torpedo , the Drosophila melanogaster homolog of the vertebrate EGF receptor gene . Genetics 123 , 771 – 787 . 10.1093/genetics/123.4.771 Cubas , P. , de Celis , J. F...

... cortex Proliferation EGF receptor Stem cell Rat Proliferation and differentiation occur in temporal and spatial patterns in the CNS. These patterns are generated as a result of intrinsic differences in progenitor cells and restricted expression of extrinsic signals (reviewed in Edlund...

..., Finland (e-mail: [email protected] ) 23 May 2000 11 April 2000 © 2000 by Company of Biologists 2000 EGF receptor Gene targeting Pancreas Matrixmetalloproteinases Mouse The pancreas develops from foregut endoderm through the fusion of dorsal and ventral...

... cells are generated, and we identify defects in precursor formation and EGF receptor-dependent inductive processes required for cell-fate specification. The number of neuronal precursors is variable in embryos that lack Spen. The levels of Suppressor of Hairless, a key transcriptional effector of Notch...

[email protected] ) 10 11 1999 12 01 2000 © 2000 by Company of Biologists 2000 TGFα EGF EGF Receptor Corneal endothelial cell Anterior segment dysgenesis Eye Transgenic mouse In mouse, the development of the anterior segment of the eye begins at about embryonic day 11 (E11...

... 1999 by Company of Biologists 1999 zfh-1 even-skipped numb Notch spitz EGF receptor Lineage Cell fate Zinc finger Homeodomain Heart Pericardial cell Myocardium Drosophila Mesoderm Cardiogenesis Myogenesis The Drosophila heart is linear and thus very different...

.... In contrast to EGF receptor (EGFR) knockout mice, triple null mice lacking half of the EGFR ligand family were healthy and fertile, indicative of overlapping or compensatory functions among EGF family members. Nevertheless, pups born to triple null dams frequently died or were runted, suggesting a mammary...

... that the segmentation genes specify neuroblast identity along the AP axis. However, little is known as to the control of neuroblast identity along the DV axis. Here, I show that the Drosophila EGF receptor (encoded by the DER gene) promotes the formation, patterning and individual fate specification of early forming...

...Amir Sapir; Ronen Schweitzer; Ben-Zion Shilo ABSTRACT Previous work has demonstrated a role for the Drosophila EGF receptor (Torpedo/DER) and its ligand, Gurken, in the determination of anterioposterior and dorsoventral axes of the follicle cells and oocyte. The roles of DER in establishing...