... of the developing lung tip epithelium in vivo . Cell shape dynamics and fate are tightly coordinated during development. We therefore used the organoid system to identify signalling pathways that maintain the columnar shape of human lung tip progenitors. We found that EGF, FGF7 and FGF10 have distinct functions...

... rhomboid regulates EGF signaling to specify distinct cell types. Recently, we identified a CRM that activates rhomboid expression and thereby EGF secretion from a subset of abdominal sensory organ precursor cells (SOPs) to induce an appropriate number of lipid-processing cells called oenocytes. Here, we...

... into normal and dysregulated nephrogenesis, as well as into regenerative processes that follow kidney injury. In this study, we found that the mouse CITED1 + progenitor compartment is maintained in response to receptor tyrosine kinase (RTK) ligands that activate both FGF and EGF receptors. This RTK signaling...

... follicle epithelium from interfollicular epidermis. Although many developmental signalling pathways are implicated in follicle morphogenesis,the role of epidermal growth factor (EGF) and keratinocyte growth factor (KGF,also known as FGF7) receptors are not defined. EGF receptor (EGFR) ligands have...

... with a potent upregulation of several members of the EGF family of mitogens. Moreover, loss of TAF4 leads to malignant transformation of chemically induced papillomas and the appearance of invasive melanocytic tumours. Together, our results show that TAF4 is an important regulator of keratinocyte proliferation...

...Byung Joon Hwang; Paul W. Sternberg During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3 , activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs. Previous studies with lin-3 mutants...

...-3( Hill and Sternberg, 1992 ), an EGF-like growth factor produced by the gonadal anchor cell induces P6.p to adopt a primary vulval fate. LET-23 ( Aroian et al., 1990 ), an EGF receptor-like tyrosine kinase, and its downstream effectors, which include LET-60 (RAS)( Beitel et al., 1990 ; Han...

... necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348 , 693 -699. Avery, L., Bargmann, C. and Horvitz, H. ( 1993 ). The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics 134...

... gene blistered . We further show that attenuation of Dpp signalling in the AP organiser is also col dependent and, in conjunction with Vein upregulation, required for formation of L4 vein. A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP...

... in isolated skin epithelium. (D-I) None of the other tested signal proteins [BMP4, EGF, FGF10, SHH and WNT6 (introduced by cell aggregates)] or BSA control beads stimulated Edar expression. (J-L) Positive controls: (J) Msx2 expression induced by BMP4. (K) Ptch ( Ptc ) induced by SHH. (L) Lef1 induced...

...Francesca Peri; Siegfried Roth ABSTRACT During Drosophila oogenesis Gurken, associated with the oocyte nucleus, activates the Drosophila EGF receptor in the follicular epithelium. Gurken first specifies posterior follicle cells, which in turn signal back to the oocyte to induce the migration...

... transgenic mice that express either transforming growth factor α (TGFα) or epidermal growth factor (EGF) in the ocular lens using the mouse αA-crystallin promoter. Expression of either growth factor alters the normal developmental fate of the innermost corneal mesenchymal cells so that these cells often fail...

...Noreen C. Luetteke; Ting Hu Qiu; Suzanne E. Fssssenton; Kelly L. Troyer; Richard F. Riedel; Aileen Chang; David C. Lee SUMMARY Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFα-knockout to generate mice lacking various combinations of the three ligands...

...Susanne Kramer; Masataka Okabe; Nir Hacohen; Mark A. Krasnow; Yasushi Hiromi ABSTRACT Extracellular factors such as FGF and EGF control various aspects of morphogenesis, patterning and cellular proliferation in both invertebrates and vertebrates. In most systems, it is primarily the distribution...

... dorsoventral domains. * Author for correspondence (e-mail: [email protected] ) 25 August 1998 1 July 1998 © 1998 by Company of Biologists 1998 Neurogenesis MAP kinase DER vnd Drosophila EGF The massive number and variety of neuronal cells that constitute...

... transcription. In particular, LIN-12::GFP is expressed initially in all six VPCs, but appears to be reduced specifically in P6.p as a consequence of the activation of the Ras pathway by an EGF-like inductive signal from the AC. We propose that downregulation of LIN-12 stability or translation in response...

... sufficient to promote the P12 fate, and the conserved EGF signaling pathway is utilized for P12 fate specification; egl-5 is a downstream target of the lin-3/let-23 pathway in specifying P12 fate; and LIN-44 and LIN-17 act synergistically with lin-3 in the specification of the P12 fate. The Wnt pathway may...

... in this communication indicate that the elevated level of fetal fibroblast migration into 3D-collagen gels and HA synthesis by these cells were not affected by epidermal growth factor (EGF), platelet-derived growth factor (PDGF), acidic fibroblast growth factor (aFGF) or basic fibroblast growth factor (bFGF...

... , 427 – 438 . Rebay , I. , Fleming , R. J. , Fehon , R. G. , Cherbas , L , Cherbas , P. and Artavanis-Tsakonis , S. ( 1991 ). Specific EGF repeats of Notch mediate interactions with Delta and Serrate : Implications for Notch as a multifunctional receptor . Cell...

... tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated. Both LIF and EGF, like the proteinases, have been implicated in peri-implantation development. Blastocysts collected on day 4 of pregnancy were cultured 2 days in TCM 199 + 10...