... attributed. Summary: This Review covers the mechanisms of primordial germ cell migration in model organisms and systems, emphasizing the guidance factors and signaling pathways necessary for colonization of the gonad. ECM Gonad Migration Primordial germ cells Signaling Eunice...

.... Summary: High-resolution imaging reveals epithelia-to-mesenchyme transition (EMT) heterogeneity on the surface of developing mouse hearts. Proteoglycan again regulates epicardial EMT through dystroglycan localising within the Golgi apparatus. Epicardium EMT ECM Agrin Dystroglycan Golgi...

... migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many...

... factors and impaired ECM remodeling/protease function. Estrogen receptor alpha Membrane initiated signaling Mammary gland Stem cells Paracrine signals ECM Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677 Université et Centre Hospitalier...

...Georg Wolfstetter; Ina Dahlitz; Kathrin Pfeifer; Uwe Töpfer; Joscha Arne Alt; Daniel Christoph Pfeifer; Reinhard Lakes-Harlan; Stefan Baumgartner; Ruth H. Palmer; Anne Holz ABSTRACT Basement membranes (BMs) are specialized layers of extracellular matrix (ECM) mainly composed of Laminin, type IV...

...Lindsay Marjoram; Christopher Wright The spatiotemporally dynamic distribution of instructive ligands within embryonic tissue, and their feedback antagonists, including inherent stabilities and rates of clearance, are affected by interactions with cell surfaces or extracellular matrix (ECM). Nodal...

... of different promoters, LTBP1 exists in two major forms, long (L) and short (S), each expressed in a temporally and spatially unique fashion. Both LTBP1 molecules covalently interact with latent TGF-β and regulate its function,presumably via interaction with the extracellular matrix (ECM). To explore...

... μg/ml,Genentech) was added and incubated for 1 hour. Cells were stained with secondary antibody in detergent-free buffers. The ECM influences many steps in vascular development( Brooke et al., 2003 ; Davis and Senger, 2005 ; Whelan and Senger, 2003 );however, the specific mechanism through...

... with an altered macromolecular composition of the ECM structuring the cells' migratory pathways. The presented results, extend our knowledge on Has2 function and, for the first time, demonstrate a developmental role for CD44 in vertebrates. On the whole, these data underlie and confirm the emerging importance...

... of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton;however, how these interactions are regulated and their basic cellular functions are poorly understood. Using...

...Hiroshi Shimizu; Xiaoming Zhang; Jinsong Zhang; Alexey Leontovich; Kaiyin Fei; Li Yan; Michael P. Sarras, Jr. As a member of the phylum Cnidaria, the body wall of hydra is organized as an epithelium bilayer (ectoderm and endoderm) with an intervening extracellular matrix (ECM). Previous studies...

...Rainer Deutzmann; Susan Fowler; Xiaoming Zhang; Keneath Boone; Sharon Dexter; Raymond P. Boot-Handford; R. Rachel; Michael P. Sarras, Jr ABSTRACT The body wall of hydra (a member of the phylum Cnidaria) is structurally reduced to an epithelial bilayer with an intervening extracellular matrix (ECM...

...Alexey A. Leontovich; Jinsong Zhang; Ken-ichi Shimokawa; Hideaki Nagase; Michael P. Sarras, Jr ABSTRACT As a member of Cnidaria, the body wall of hydra is structurally reduced to an epithelial bilayer with an intervening extracellular matrix (ECM). Biochemical and cloning studies have shown...