..., we present data indicating that the ecdysone response hierarchy also mediates egg chamber maturation during mid-oogenesis. E75, E74 and BR-C are expressed in a stage-specific manner while EcR expression is ubiquitous throughout oogenesis. Decreasing or increasing the ovarian ecdysone titer using...

...Jennifer C. Fletcher; Kenneth C. Burtis; David S. Hogness; Carl S. Thummel ABSTRACT The steroid hormone ecdysone initiates Drosophila metamorphosis by reprogramming gene expression during late larval and prepupal development. The ecdysone-inducible gene E74 , a member of the ets proto-oncogene...

... as regulators that both repress their own expression and induce a large set of secondary-response late genes. We have identified recessive loss-of-function mutations in the early gene E74 , a member of the ets protooncogene family that encodes two related DNA-binding proteins, E74A and E74B. These mutations...