.../ Highlighted Article: Two geminin family proteins function in mammalian multiciliated cell development: GMNC regulates precursor specification and MCIDAS induces multiple basal body formation for multiciliation. Cilia Multiciliated cell GMNC MCIDAS E2F Deuterosome The health of our airways...

... retinal pigment epithelium, photoreceptor loss and early onset of retinal degeneration. Although the retinal defect is associated with increased cyclin D1 and CDK4/6 expression, and RB phosphorylation and E2F-target gene upregulation, it is independent of the EOB phenotype and of JNK. The retinal...

... interacts with a novel BED (BEAF and Dref) finger protein that we have termed Sunspot (Ssp). Ssp transactivates Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland cells. Wg negatively regulates...

... , and in these cells the induction of p27 Dap activates Rbf1 to repress E2f1-target genes to maintain a stable G1 arrest. † Author for correspondence (e-mail: duronio@med.unc.edu ) * These authors contributed equally to this work 14 11 2006 © 2007. 2007 Drosophila E2F pRb Cell...

...Woo Chi; Valerie Reinke In Caenorhabditis elegans , EFL-1 (E2F), DPL-1 (DP) and LIN-35(pRb) act coordinately in somatic tissues to inhibit ectopic cell division,probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act...

.../S transition in the second mitotic wave, rather it delays the completion of S phase and leads to abnormal eye development. These observations suggest that RB/E2F control the rate of S-phase progression instead of G1/S transition in the second mitotic wave. Characterization of the role of RBF...

...-expressing Tkv Q253D and RBF, a Drosophila retinoblastoma homolog. RBF negatively regulates E2F activity and specifically suppresses cell cycle progression when overexpressed ( Du et al., 1996 ; Neufeld et al., 1998 ; Datar et al., 2000 ). Clones of cells co-expressing RBF and Tkv Q253D contained...

...Pelin Cayirlioglu; Peter C. Bonnette; M. Ryan Dickson; Robert J. Duronio Drosophila contains two members of the E2F transcription factor family ( E2f and E2f2 ), which controls the expression of genes that regulate the G1-S transition of the cell cycle. Previous genetic analyses have indicated...