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Keywords: E2F
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Journal Articles
Journal: Development
Development (2019) 146 (6): dev172643.
Published: 15 March 2019
.../ Highlighted Article: Two geminin family proteins function in mammalian multiciliated cell development: GMNC regulates precursor specification and MCIDAS induces multiple basal body formation for multiciliation. Cilia Multiciliated cell GMNC MCIDAS E2F Deuterosome The health of our airways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4001–4012.
Published: 15 September 2011
... retinal pigment epithelium, photoreceptor loss and early onset of retinal degeneration. Although the retinal defect is associated with increased cyclin D1 and CDK4/6 expression, and RB phosphorylation and E2F-target gene upregulation, it is independent of the EOB phenotype and of JNK. The retinal...
Journal Articles
Journal: Development
Development (2010) 137 (10): 1755–1764.
Published: 15 May 2010
... interacts with a novel BED (BEAF and Dref) finger protein that we have termed Sunspot (Ssp). Ssp transactivates Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland cells. Wg negatively regulates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 467–478.
Published: 1 February 2007
... , and in these cells the induction of p27 Dap activates Rbf1 to repress E2f1-target genes to maintain a stable G1 arrest. † Author for correspondence (e-mail: duronio@med.unc.edu ) * These authors contributed equally to this work 14 11 2006 © 2007. 2007 Drosophila E2F pRb Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (16): 3147–3157.
Published: 15 August 2006
...Woo Chi; Valerie Reinke In Caenorhabditis elegans , EFL-1 (E2F), DPL-1 (DP) and LIN-35(pRb) act coordinately in somatic tissues to inhibit ectopic cell division,probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (6): 1345–1356.
Published: 15 March 2002
.../S transition in the second mitotic wave, rather it delays the completion of S phase and leads to abnormal eye development. These observations suggest that RB/E2F control the rate of S-phase progression instead of G1/S transition in the second mitotic wave. Characterization of the role of RBF...
Journal Articles
Journal: Development
Development (2002) 129 (4): 1003–1013.
Published: 15 February 2002
...-expressing Tkv Q253D and RBF, a Drosophila retinoblastoma homolog. RBF negatively regulates E2F activity and specifically suppresses cell cycle progression when overexpressed ( Du et al., 1996 ; Neufeld et al., 1998 ; Datar et al., 2000 ). Clones of cells co-expressing RBF and Tkv Q253D contained...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5085–5098.
Published: 15 December 2001
...Pelin Cayirlioglu; Peter C. Bonnette; M. Ryan Dickson; Robert J. Duronio Drosophila contains two members of the E2F transcription factor family ( E2f and E2f2 ), which controls the expression of genes that regulate the G1-S transition of the cell cycle. Previous genetic analyses have indicated...