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Keywords: E-cadherin
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Journal Articles
Journal: Development
Development (2020) 147 (24): dev186403.
Published: 21 December 2020
... Summary: This Spotlight article reviews how Suzanne Eaton, a pioneer in the field of developmental tissue mechanics, connected quantitative cell behavior with physical modeling to reveal fundamental insights into epithelial morphogenesis. Drosophila E-cadherin Cell packing geometry Junctional...
Journal Articles
Journal: Development
Development (2020) 147 (7): dev179648.
Published: 14 April 2020
.... Endocytic activity gradually reduces as tissue remodeling progresses. This reduced endocytic activity accelerates cell elimination through the regulation of Myosin II subcellular reorganization, junctional E-cadherin levels, and caspase activation. Whereas the increased Myosin II dynamics accelerates cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev179606.
Published: 11 March 2020
... pupal development. Extrusion of these LECs is not closely preceded by caspase activation, involves a pulsatile medial actomyosin network, and correlates with a developmental time period when mechanical tension and E-cadherin turnover at adherens junctions is particularly high. Our work reveals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
... of the primitive streak (PS) by WNT. In the pluripotent state, E-cadherin (E-CAD) transduces boundary forces to focus WNT signaling to the colony border. Following application of WNT ligand, E-CAD mediates a front or wave of epithelial-to-mesenchymal (EMT) conversion analogous to PS extension in an embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2200–2211.
Published: 15 June 2017
... results in more tightly packed outer bud cells, which display stronger E-cadherin localization, reduced cell motility and decreased dynamics of transient cell separations associated with cleft formation; inner bud cells remain unaffected. Mechanistic analyses using in vitro MDCK cells to mimic outer bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1778–1787.
Published: 15 May 2016
.... Our results show that E-cadherin is intensely expressed in germline cysts, and that its decline is necessary for oocyte release from the cyst. However, inhibition of JNK signaling leads to aberrantly enhanced localization of E-cadherin at oocyte-oocyte contact sites. WNT4 expression is upregulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1512–1522.
Published: 01 May 2016
...) as a direct NF-κB target gene, loss of which replicates a subset of phenotypes seen in NF-κB-deficient embryos. Lhx2 and Tgfb2 knockout embryos exhibit very similar abnormalities in HF development, including failure of the E-cadherin suppression required for follicle down-growth. We show that TGFβ2 signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 101–112.
Published: 01 January 2016
... Epithelium Stratification Pdx1 Microlumen Lumen diameter E-cadherin Cdh1 β-catenin Endocrine pMLC Insulin-producing β-cells are crucial for proper blood glucose homeostasis. These cells are of particular interest since diabetes, which affects millions of people worldwide and causes both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1777–1784.
Published: 15 May 2015
...Elise Houssin; Ulrich Tepass; Patrick Laprise E-cadherin-mediated cell-cell adhesion is fundamental for epithelial tissue morphogenesis, physiology and repair. E-cadherin is a core transmembrane constituent of the zonula adherens (ZA), a belt-like adherens junction located at the apicolateral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1684–1694.
Published: 01 May 2015
...Ghislain Gillard; Massiullah Shafaq-Zadah; Ophélie Nicolle; Raghida Damaj; Jacques Pécréaux; Grégoire Michaux E-cadherin (E-cad) is the main component of epithelial junctions in multicellular organisms, where it is essential for cell-cell adhesion. The localisation of E-cad is often strongly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1684–1692.
Published: 15 April 2013
... growth morphology, results from tight cell adhesion mediated through E-cadherin, β-catenin (Ctnnb1) and α-catenin with the actin cytoskeleton. β-catenin is also involved in canonical Wnt signaling, which has also been suggested to control mES cell stemness. Here, we analyze Ctnnb1 -/- mES cells in which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 1045–1054.
Published: 01 March 2013
... trafficking of E-cadherin (E-cad), but how this process can be polarised within individual cells is poorly understood. The Frizzled (Fz)-dependent core planar polarity pathway is a major regulator of polarised cell rearrangements in processes such as gastrulation, and has also been implicated in regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1447–1456.
Published: 15 April 2012
...David E. Metzger; Malgorzata Gasperowicz; Florian Otto; James C. Cross; Gerard Gradwohl; Kenneth S. Zaret Pancreatic β-cells arise from Ngn3 + endocrine progenitors within the trunk epithelium of the embryonic pancreas. The emergence of endocrine cells requires E-cadherin downregulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2705–2715.
Published: 01 July 2011
... mesoderm cell protrusions. These protrusions extend deep into the underlying ectoderm epithelium and are associated with high levels of E-cadherin at the germ layer interface. Finally, FGF directs distinct hitherto unrecognised and partially redundant protrusive behaviours during later mesoderm spreading...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3383–3391.
Published: 15 October 2010
... that in mouse embryos completely lacking both maternal and zygotic E-cadherin (cadherin 1), the normal epithelial morphology of outside cells is disrupted, but individual cells still initiate TE- and ICM-like fates. A larger proportion of cells than normal showed expression of TE markers such as Cdx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (7): 1355–1364.
Published: 01 April 2008
...Masayo Shindo; Housei Wada; Masako Kaido; Minoru Tateno; Toshiro Aigaki; Leo Tsuda; Shigeo Hayashi The downregulation of E-cadherin by Src promotes epithelial to mesenchymal transition and tumorigenesis. However, a simple loss of cell adhesion is not sufficient to explain the diverse developmental...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 425–429.
Published: 01 February 2008
... homology domains to monitor PtdIns(3,4,5) P 3 synthesis, we show that PI3K is constitutively activated in mouse preimplantation embryos. E-cadherin ligation promotes PtdIns(3,4,5) P 3 synthesis at sites of blastomere adhesion at all cleavage stages. In addition, in culture conditions that promote autocrine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 501–511.
Published: 01 February 2008
... specification in the mouse. * Author for correspondence (e-mail: elizabeth.robertson@path.ox.ac.uk ) 13 11 2007 © 2008. 2008 Eomesodermin Nodal Axis formation EMT E-cadherin Endoderm specification Mouse The coordinated activities of multiple signalling pathways...
Journal Articles
Journal: Development
Development (2007) 134 (24): 4381–4393.
Published: 15 December 2007
... of e-cadherin , thereby perturbing cell movements during convergent extension, epiboly and node formation. Thus, although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (22): 4073–4081.
Published: 15 November 2007
... expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J. Neurosci. 14 , 3475 -3486. Babb, S. G. and Marrs, J. A. ( 2004 ). E-cadherin regulates cell movements and tissue formation in early zebrafish embryos. Dev. Dyn. 230 , 263 -277. Barrallo...
Includes: Multimedia, Supplementary data