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Keywords: Dystrophin
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Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (21): 3597–3606.
Published: 1 November 2009
.... ( 2006 ). Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin. J. Cell Sci. 119 , 2185 -2195. Schmalbruch, H. ( 1975 ). Segmental fiber breakdown and defects of the plasmalemma in diseased human muscles. Acta Neuropathol. 33 , 129 -141. Schwander, M., Leu, M., Stumm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3805–3815.
Published: 1 October 2006
... and epithelial development. As an integral component of the Dystrophin-associated glycoprotein complex, Dg plays a central role in linking the ECM and the cytoskeleton. Disruption of this linkage in skeletal muscle leads to various types of muscular dystrophies. In epithelial cells, reduced expression of Dg...
Journal Articles
Journal: Development
Development (2006) 133 (10): 1911–1921.
Published: 15 May 2006
... are fertile but show gonad migration defects in addition to the defects seen in homozygotes, indicating that DGN-1 function is dosage sensitive. Phenotypic analyses show that DGN-1 and dystrophin-associated protein complex (DAPC)components have distinct and independent functions, in contrast to the situation...
Journal Articles
Journal: Development
Development (2003) 130 (23): 5851–5860.
Published: 1 December 2003
... in a dystrophic pathology through disconnecting the cytoskeleton from the extracellular matrix in skeletal muscle by reducing the level of dystrophin protein at the sarcolemma. This is thought to allow tearing of this membrane, which in turn leads to cell death. Surprisingly, we have found that the progressive...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3505–3512.
Published: 15 July 2002
...Michael J. Parsons; Isabel Campos; Elizabeth M. A. Hirst; Derek L. Stemple Muscular dystrophy is frequently caused by disruption of the dystrophin-glycoprotein complex (DGC), which links muscle cells to the extracellular matrix. Dystroglycan, a central component of the DGC, serves as a laminin...
Journal Articles
Journal: Development
Development (1992) 116 (3): 721–730.
Published: 1 November 1992
... attachments and may be involved in myotube migration on the ectoderm. 3 7 1992 © 1992 by Company of Biologists 1992 Drosophila muscle muscle attachments α-actinin dystrophin integrin Muscle differentiation and the development of muscle pat-terning in the Drosophila embryo...
Journal Articles
Journal: Development
Development (1992) 114 (2): 395–402.
Published: 1 February 1992
...Angela Clerk; Peter N. Strong; Caroline A. Sewry ABSTRACT Dystrophin, the 427 × 10 3 M r product of the Duchenne muscular dystrophy (DMD) gene, was studied in human foetal skeletal muscle from 9 to 26 weeks of gestation. Dystrophin could be detected from at least 9 weeks of gestation...