... development of the epicardium, accompanied by downregulation of Wilms’ tumor 1. Agrin enhanced EMT in human embryonic stem cell-derived epicardial-like cells by decreasing β-catenin and promoting pFAK localization at focal adhesions, and promoted the aggregation of dystroglycan within the Golgi apparatus...

... impact on elongation are unclear. We found that Dystroglycan (Dg) and Dystrophin (Dys) are involved in BM fibril deposition. Moreover, they also orient stress fibers, by acting locally and in parallel to Fat2. Importantly, Dg-Dys complex-mediated cell-autonomous control of F-actin fiber orientation...

... progenitors in a proliferative state via integrins α6β1 and α7β1, whereas low concentrations of lm211 support mDA lineage survival via dystroglycan receptors. We confirmed our findings in vivo , demonstrating that the VM was smaller in the absence of lm-α2, with increased apoptosis; furthermore...

...Nicolas Buisson; Cathy Sirour; Nicole Moreau; Elsa Denker; Ronan Le Bouffant; Aline Goullancourt; Thierry Darribère; Valérie Bello Dystroglycan (Dg) is a transmembrane receptor for laminin that must be expressed at the right time and place in order to be involved in notochord morphogenesis...

... of the Large and fukutin substrate dystroglycan does not result in radial sorting defects. Here, we show that absence of dystroglycan in a specific genetic background causes sorting defects with topography identical to that of laminin 211 mutants, and recapitulating the MDC1A, MDC1D and Fukuyama phenotypes...

.... It has been proposed that, given their central role in mediating extracellular matrix (ECM) interactions, integrin receptors are likely to be involved. However, it is a non-integrin ECM receptor,dystroglycan, that provides the key linkage between the dystrophin-glycoprotein complex (DGC) and laminin...

...Martina Schneider; Ashraf A. Khalil; John Poulton; Casimiro Castillejo-Lopez; Diane Egger-Adam; Andreas Wodarz; Wu-Min Deng; Stefan Baumgartner Dystroglycan (Dg) is a widely expressed extracellular matrix (ECM) receptor required for muscle viability, synaptogenesis, basementmembrane formation...

...Robert P. Johnson; Seong Hoon Kang; James M. Kramer The C. elegans dystroglycan (DG) homolog DGN-1 is expressed in epithelia and neurons, and localizes to basement membrane (BM) surfaces. Unlike vertebrate DG, DGN-1 is not expressed in muscle or required for muscle function. dgn-1 null mutants...

...Wu-Min Deng; Martina Schneider; Richard Frock; Casimiro Castillejo-Lopez; Emily Anne Gaman; Stefan Baumgartner; Hannele Ruohola-Baker The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms...

...Michael J. Parsons; Isabel Campos; Elizabeth M. A. Hirst; Derek L. Stemple Muscular dystrophy is frequently caused by disruption of the dystrophin-glycoprotein complex (DGC), which links muscle cells to the extracellular matrix. Dystroglycan, a central component of the DGC, serves as a laminin...

...James T. Campanelli; Gregory G. Gayer; Richard H. Scheller ABSTRACT Agrin is a component of the extracellular matrix that regulates aspects of neuromuscular junction differentiation. Identification of agrin-binding proteins has lead to the suggestion that α-dystroglycan is a muscle cell surface...