...Mercedes Martín; Cristina M. Ostalé; Jose F. de Celis Pattern formation relies on the generation of transcriptional landscapes regulated by signalling pathways. A paradigm of epithelial patterning is the distribution of vein territories in the Drosophila wing disc. In this tissue, Decapentaplegic...

...Qiuheng Lu; Dorothy A. Schafer; Paul N. Adler The evolutionarily conserved frizzled/starry night ( fz/stan ) pathway regulates planar cell polarity (PCP) in vertebrates and invertebrates. This pathway has been extensively studied in the Drosophila wing, where it is manifested by an array...

... Drosophila wing Growth Image analysis In vivo imaging Mathematical analysis Morphogenesis Attempts to immobilize Drosophila larvae for imaging have already been performed. They consist of either squeezing ( Ghannad-Rezaie et al., 2012 ; Nienhaus et al., 2012 ) or anesthetizing ( Füger et...

...Liyuan Sui; Gert O. Pflugfelder; Jie Shen The Drosophila wing imaginal disc is subdivided into notum, hinge and blade territories during the third larval instar by formation of several deep apical folds. The molecular mechanisms of these subdivisions and the subsequent initiation of morphogenic...

...Myriam Zecca; Gary Struhl Following segregation of the Drosophila wing imaginal disc into dorsal (D) and ventral (V) compartments, the wing primordium is specified by activity of the selector gene vestigial ( vg ). In the accompanying paper, we present evidence that vg expression is itself driven...

...Myriam Zecca; Gary Struhl The Drosophila wing primordium is defined by expression of the selector gene vestigial ( vg ) in a discrete subpopulation of cells within the wing imaginal disc. Following the early segregation of the disc into dorsal (D) and ventral (V) compartments, vg expression...

... transcription. In the Drosophila wing, expression of genes such as omb and sal along the anteroposterior axis is restricted by lateral-to-medial gradients of the transcriptional repressor Brinker (Brk). omb is less sensitive to repression by Brk than sal and is consequently expressed more laterally. Contrary...