... attributed. Summary: Optogenetic tools can be used to determine how transcription factor levels and nuclear retention impact a dynamic patterning process. Dorsal transcription factor Drosophila melanogaster LEXY and B-LID Dorsal-ventral patterning Gene expression dynamics Optogenetics...

... is a multifunctional protein mediating lipid uptake, mobilization and signaling at the plasma membrane and inside of the cell. The CD36 protein family has 14 members in Drosophila melanogaster , which allows for the differentiated analysis of their functions. Here, we unravel a role for the so far uncharacterized...

... 2024. Published by The Company of Biologists Ltd 2024 Summary: Tyrosine catabolism is dynamically regulated in Drosophila epidermal tissue in response to dietary protein intake. Tyrosine High-protein diet Drosophila melanogaster Epidermal metabolism FoxO AMPK Insulin/IGF-1...

...Albert Tsai; Justin Crocker ABSTRACT An embryo experiences increasingly complex spatial and temporal patterns of gene expression as it matures, guiding the morphogenesis of its body. Using super-resolution fluorescence microscopy in Drosophila melanogaster embryos, we observed that the nuclear...

...) #24749]. All flies used were strains of Drosophila melanogaster and reared at 25°C on standard fly media. See Table S1 for details regarding stocks used. Our observation of increased pMad + cell number in germline-specific brk mutants or RNAi was surprising given our findings...

.... Nanobody Nucleus GFP maturation Live in vivo imaging Cell tracking Drosophila melanogaster National Institutes of Health http://dx.doi.org/10.13039/100000002 R35GM118146 American Heart Association http://dx.doi.org/10.13039/100000968 18POST34080493 California...

.../eLife.28275.026 Harrison , M. M. , Li , X.-Y. , Kaplan , T. , Botchan , M. R. and Eisen , M. B. ( 2011 ). Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition . PLoS Genet. 7 , e1002266...

... veins . Annu. Rev. Genet.   1940 , 28 . Grieder , N. C. , Morata , G. , Affolter , M. and Gehring , W. J. ( 2009 ). Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc . Dev. Biol.   329 , 315 - 326...

.../ Summary: Collectively migrating cells not only respond to extrinsic molecular cues and surrounding topology, but can also physically modify the morphogenesis of their tissue substrate. Drosophila melanogaster Caudal visceral mesoderm CVM Trunk visceral mesoderm TVM Fibroblast growth factor...

... by guidance signals towards somatic gonadal precursor cells (SGPs). In Drosophila melanogaster , SGP-derived Hedgehog (Hh), which serves as a guidance cue for the PGCs, is potentiated by mesodermally restricted HMGCoA-reductase (Hmgcr) and the ABC transporter Multi-drug-resistant-49 (Mdr49). Given...

... development. Drosophila melanogaster Embryogenesis lncRNA Spatiotemporal transcriptome Neurogenesis Deutsche Forschungsgemeinschaft 10.13039/501100001659 SPP1738 National Institutes of Health 10.13039/100000002 HG004037 Wellcome Trust 10.13039/100010269 U41...

...-1/ Summary: In Drosophila , neuroblasts and cortex glia use a receptor tyrosine kinase-dependent feed-forward mechanism to actively maintain each other during neurogenesis, which contributes to glial tumorigenesis. Niche Glia Neuroblast PDGFR Drosophila melanogaster...

..., 2013 ). Drosophila melanogaster Epithelial-to-mesenchymal (EMT) Mesenchymal-to-epithelial (MET) Fibroblast growth factor (FGF) Adherens junction Integrin Bazooka Summary: FGF regulates epithelial-mesenchymal transition in mesoderm to support collective movement at gastrulation...

... requirements for effective Hh shedding remained undefined. In this work, by using Drosophila melanogaster as a model, we show that mutagenesis of the N-terminal Cardin–Weintraub (CW) motif inactivates recombinant Hh proteins to variable degrees and, if overexpressed in the same compartment, converts them...

... PNS during early pupal phase. Dendrite Pruning Microtubule Kinesin Plus end Drosophila melanogaster The physiological degeneration of synapses, axons or dendrites without loss of the parent neuron is known as pruning. Pruning is an important developmental mechanism that is used...

... Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki City, Nagasaki 852-8523, Japan. Mbf1 Enhancer of zeste E(z) Polycomb silencing Pcm Exoribonuclease Drosophila melanogaster Japan Science and Technology Agency 10.13039/501100002241 Japan Society...

... transients modulate the temporal dynamics of Dpp presentation in developmental BMP signaling, impacting the downstream transcriptional response and tissue morphogenesis. Fly wing morphogenesis Dpp BMP Bioelectric signaling KCNJ2 Drosophila melanogaster National Science Foundation...

..., by both a cullin-mediated EGFR-dependent mechanism and by an alternative route. Capicua COP9 signalosome Drosophila melanogaster EGFR Nedd8 Ubiquitin ligase Wing disc National Institutes of Health 10.13039/100000002 EY13777 Regulation of protein stability...

.... Wingless Wnt Shavenbaby Ovo SoxNeuro Denticle Morphogenesis Drosophila melanogaster Information from signaling pathways must be interpreted and modulated for the proper execution of cellular events during development. Much of developmental biology research has focused on the signaling...

... is essential for efficient pre-mRNA splicing. Drosophila melanogaster Tracheal system Branching morphogenesis mRNA splicing Spliceosome Faint sausage Fandango Boehringer Ingelheim Fonds 10.13039/501100001645 Schweizerischer Nationalfonds zur Förderung der...