... and metamorphosis. Here, we test this by examining the consequences of null mutations in the P tth gene for Drosophila development. Loss of P tth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth...

...-activating kinase Drosophila development Considering the countless insults that DNA and chromosomes have to sustain, it is amazing how faithfully the genome is duplicated and passed on to daughter cells during mitosis. mms19 was first identified in Saccharomyces cerevisiae as a gene...

.... Precision Accuracy Drosophila development Embryo Transcriptional regulation Modeling In animals, changes in gene regulation are associated with phenotypic changes within and between species ( Chen and Rajewsky, 2007 ; Gompel et al., 2005 ; McGregor et al., 2007 ; Simpson, 2007 ; Wittkopp...

... of development and differentiation. * Authors for correspondence (e-mails: mfang@seu.edu.cn ; dressler@umich.edu ) 20 3 2009 © 2009. 2009 Epigenetics Polycomb Trithorax ptip Drosophila development The establishment and maintenance of gene expression patterns...

...Savita Ayyar; Jianqiao Jiang; Anna Collu; Helen White-Cooper; Robert A. H. White We have investigated the role of TGIF, a TALE-class homeodomain transcription factor, in Drosophila development. In vertebrates, TGIF has been implicated, by in vitro analysis, in several pathways, most notably...

...-mail: tian.xu@yale.edu ) 17 09 1999 09 11 1999 © 1999 by Company of Biologists 1999 Drosophila development PTEN tumor suppressor Cell size Proliferation Apoptosis Insulin-signaling The tumor suppressor gene PTEN is one of the most frequently mutated genes involved...

...-mail: mack@nibb.ac.jp ) 25 8 1998 30 9 1998 © 1998 by Company of Biologists 1998 Drosophila development Imaginal disc decapentaplegic wingless Sensory organ Pattern formation Two types of sensory organs, large bristles (macrochaetes) and small bristles...

... caused by loss of wg function ( Theisen et al., 1994 ; Klingensmith et al., 1994 ) while loss of sgg generates ectopic patterns similar to those caused by ectopic expression of wg ( Diaz-Benjumea and Cohen, 1994 ). Drosophila development shaggy gene zeste white 3 gene dishevelled...

... Drosophila development imaginal disc wingless decapentaplegic dishevelled punt thick veins wingless regulation dpp regulation pattern formation The generation of at least three axes of asymmetry in appendage primordia is an essential element of patterning (see Postlethwait...

.... A. H. ( 1992 ). The 412 retrotransposon and the development of gonadal mesoderm in Drosophila . Development 116 , 1185 – 1192 . 10.1242/dev.116.4.1185 Brown , N. H. and Kafatos , F. C. ( 1988 ). Functional cDNA libraries from Drosophila embryos . J. Mol. Biol . 203...

... ). It is required in a cell autonomous manner for response to the wingless signal during adult patterning and thus is placed downstream of the wingless signal ( Peifer et al., 1991 ). The dishevelled gene ( dsh ) is required for at least two functions in Drosophila development, namely, establishment...

... in Drosophila development. (A) Since the somatic musculature in mys embryos prematurely pulls away from hypodermal cells and since antibody localization studies place the PS integrins in embryonic muscle attachments (See text for references) a likely function for the PS integrins is to keep the somatic...

..., Berkeley, CA 94720, USA 15 03 1993 © 1993 by Company of Biologists 1993 steroid hormones gene regulation ecdysone Drosophila development Pulses of the steroid hormone 20-hydroxyecdysone (hence-forth referred to as ecdysone) function as temporal signals that trigger...

... of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA * Author for correspondence 28 09 1992 © 1993 by Company of Biologists 1993 Drosophila development bithorax complex homeotic gene...

... genes. 29 09 1992 © 1993 by Company of Biologists 1993 Drosophila development Homeotic gene regulation trans-regulatory factor trithorax The homeotic genes of the bithorax and Antennapedia complexes (BX-C and ANT-C) encode a family of related transcription-regulatory...

... of screens ( Bastiani et al., 1987 ; Patel et al., 1987 ; Harrelson and Goodman, 1988 ; Snow et al., 1988 ). The cloned sequences for fasciclin I and II were used to isolate homologs in Drosophila ( Zinn et al., 1988 ; Grenmngloh et al., 1990, 1991). adhesion molecule Drosophila development...

...Albert V. Smith; Terry L. Orr-Weaver ABSTRACT The process of polytenization plays a crucial role in Drosophila development, and most of the larval tissues are polytene. By analyzing the pattern of DNA replication in embryos pulse-labeled with BrdU, we show that many larval tissues undergo...

... by Company of Biologists 1991 Drosophila development bithorax complex transcriptional regulation cis -regulatory elements Early in the development of Drosophila melanogaster , a number of maternal and zygotic genes divide the embryo into metameres and provide positional information...

...ALisa L. Katzen; Thomas Kornberg; J. Michael Bishop We used in situ hybridization to study the RNA expression of the dsrc29A gene during Drosophila development. This gene encodes two proteins differing at their amino termini. Both gene products contain a protein-tyrosine kinase domain and resemble...

...Marek Mlodzik; Greg Gibson; Walter J. Gehring ABSTRACT The effects of heat-shock-induced ectopic expression of the homeobox gene caudal (cad) at all stages of Drosophila development have been examined. Presence of cad protein (CAD) at the anterior end of cellular blastoderm embryos was found...