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Keywords: Drosophila
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev197343.
Published: 26 April 2021
...’ cells, to drive stress resilience during Drosophila renal development and homeostasis . Renal tubules lacking Gadd45 exhibit striking morphogenetic defects (with cell death, inflammatory infiltration and reduced ploidy) and accumulate significant DNA damage in post-embryonic life. In parallel, the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197087.
Published: 23 April 2021
... MAP kinases p38 and JNK. The sustained or high activation of these kinases can result in apoptosis, whereas short or low activation can promote regeneration. Using the Ask1-dependent regeneration program, we demonstrate in Drosophila wing that PI3K/Akt signaling is necessary for Ask1 to activate p38...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.198796.
Published: 19 April 2021
... developmental or physiological role to be assigned to the wild type gene. We previously observed that the concurrent loss of Pax6 and Polycomb epigenetic repressors in Drosophila leads the eye to transform into a wing. This fate change is not seen when either factor is disrupted separately. An implication of...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev189258.
Published: 15 April 2021
... controls production of the second messenger 3′,5′-cyclic adenosine monophosphate (cAMP). cAMP in turn activates Protein kinase A (PKA), which functions as an inhibitor and (uniquely in Drosophila ) as an activator of Hh signalling. A few mammalian Gαi- and Gαs-coupled G protein-coupled receptors (GPCRs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev192344.
Published: 06 April 2021
... tissues over many temporal and spatial scales: BMP gradients as short as 1-2 cell diameters maintain the stem cell niche of the Drosophila germarium over a 24-h cycle, and BMP gradients of several hundred microns establish dorsal-ventral tissue specification in Drosophila , zebrafish and Xenopus embryos...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196956.
Published: 31 March 2021
...Juan Lu; Wei Dong; Yan Tao; Yang Hong ABSTRACT Discs large (Dlg) is an essential polarity protein and a tumor suppressor originally characterized in Drosophila but also well conserved in vertebrates. Like the majority of polarity proteins, plasma membrane (PM)/cortical localization of Dlg is...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev195057.
Published: 19 March 2021
...Danielle DaCrema; Rajan Bhandari; Faith Karanja; Ryunosuke Yano; Adrian Halme ABSTRACT Regeneration of Drosophila imaginal discs, larval precursors to adult tissues, activates a regeneration checkpoint that coordinates regenerative growth with developmental progression. This regeneration checkpoint...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 09 March 2021
... Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev190868.
Published: 10 January 2021
...Myung-Jun Kim; Michael B. O'Connor ABSTRACT The Myostatin/Activin branch of the TGF-β superfamily acts as a negative regulator of vertebrate skeletal muscle size, in part, through downregulation of insulin/insulin-like growth factor 1 (IGF-1) signaling. Surprisingly, recent studies in Drosophila...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186346.
Published: 21 December 2020
... organogenesis, and it regulates many aspects of cell positioning and orientation during tissue morphogenesis, organ development and homeostasis. Suzanne Eaton used the power of Drosophila as a model system to study PCP, but her vision of, and impact on, PCP studies in flies translates to all animal models. As I...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186403.
Published: 21 December 2020
... polarity in the wing epithelium of Drosophila . Cell   142 , 773 - 786 . 10.1016/j.cell.2010.07.042 Bertet , C. , Sulak , L. and Lecuit , T. ( 2004 ). Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation . Nature   429 , 667 - 671...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186411.
Published: 21 December 2020
... cellular homeostasis and animal development. This theme was central to Suzanne Eaton's research in the fruit fly, Drosophila . Here, we discuss her work on membrane lipid homeostasis in changing environments and on functions for lipids in the Hedgehog signalling pathway. We further highlight lipoproteins...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev191874.
Published: 16 December 2020
... balancing synaptic GluR subtypes remain unclear. Herein, we show that the two subtypes of GluRs (A and B) expressed at Drosophila neuromuscular junction synapses mutually antagonize each other in terms of their relative synaptic levels and affect subsynaptic localization of each other, as shown by super...
Journal Articles
Journal: Development
Development (2020) 147 (23): dev194316.
Published: 04 December 2020
... generation at apical, lateral or basal sides of epithelial Drosophila wing disc cells, an important model for studying morphogenesis. We show that optogenetic recruitment of RhoGEF2 to apical, lateral or basal cell sides leads to local accumulation of F-actin and increase in mechanical tension. Increased...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev191544.
Published: 23 November 2020
... asymmetric cell division, progenitors send a Delta-Notch signal to their sibling stem cells. Here, we show that excessive activation of Notch or overexpression of its direct targets of the Hes family causes stem-cell hyperplasias in the Drosophila larval central nervous system, which can progress to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190124.
Published: 17 November 2020
.... However, the molecular mechanisms of Drosophila epithelial cell extrusion are not fully understood. Here, we report that activation of the conserved Hippo (Hpo) signaling pathway induces both apical and basal cell extrusion in the Drosophila wing disc epithelia. We show that canonical Yorkie targets Diap1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev195974.
Published: 17 November 2020
...Ryo Hatori; Thomas B. Kornberg ABSTRACT Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev191411.
Published: 28 September 2020
..., causative mutations can be difficult to pinpoint because variants frequently map to genes with no previous disease associations and, often, only one or a few patients with variants in the same gene are identified. Model organisms, such as Drosophila , can help to identify and characterize these new disease...
Journal Articles
Journal: Development
Development (2020) 147 (17): dev191049.
Published: 11 September 2020
... membrane at cell-cell and cell-matrix junctions. Here, we review three morphogenetic events common to most animals: apical constriction, convergent extension and collective cell migration. Using the fruit fly Drosophila as an example, we discuss recent work that has revealed exciting new insights into the...
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186593.
Published: 07 August 2020
... does not form immobile complexes at the lateral domain of Drosophila follicle cells. Optogenetic depletion of plasma membrane PIP 2 or dlg mutants accelerate Lgl cortical dynamics. However, Dlg and Scrib are required only for Lgl localization and dynamic behavior in the presence of aPKC function...
Includes: Supplementary data