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Keywords: Drosophila
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200456.
Published: 16 May 2022
...Uwe Töpfer; Karla Yanín Guerra Santillán; Elisabeth Fischer-Friedrich; Christian Dahmann ABSTRACT The basement membrane is a specialized extracellular matrix (ECM) that is crucial for the development of epithelial tissues and organs. In Drosophila , the mechanical properties of the basement...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.200355.
Published: 3 May 2022
... to the immunoglobulin superfamily, in Drosophila larval motor neurons (MNs), muscles, glia, and sensory neurons (SNs), using a collection of GAL4 driver lines. We found that dprs are more broadly expressed than DIPs in MNs and SNs, and each examined neuron expresses a unique combination of dprs and DIPs . Interestingly...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200217.
Published: 31 March 2022
.... Here, we show that the zinc-finger transcription factor Blimp-1 acts in secondary and tertiary pigment cells in the Drosophila retina to promote the formation of a bi-convex corneal lens with normal refractive power, and in cone cells to enable complete extension of the photoreceptor rhabdomeres. Blimp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev199987.
Published: 31 March 2022
... brain size. One such gene is TRAIP , which has multiple functions in DDR. We characterized the Drosophila TRAIP homolog nopo , hereafter traip , and found that traip mutants ( traip − ) have a brain-specific defect in the mushroom body (MB). traip − MBs were smaller and contained fewer neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200491.
Published: 28 March 2022
...Jason W. Millington; Puja Biswas; Charlotte Chao; Yi Han Xia; Lianna W. Wat; George P. Brownrigg; Ziwei Sun; Paige J. Basner-Collins; Ramon I. Klein Geltink; Elizabeth J. Rideout ABSTRACT In Drosophila , changes to dietary protein elicit different body size responses between the sexes. Whether...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200243.
Published: 23 March 2022
... but generation of these strains is still labor-intensive work. To overcome this, we have developed a versatile Drosophila toolkit with a genetically encoded single-chain variable fragment for the HA epitope tag: ‘HA Frankenbody’. This system allows various analyses of HA-tagged POI in live tissues by simply...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200159.
Published: 16 March 2022
..., activation of patched ( ptc ) in response to Hh is part of a negative feedback loop limiting the range of the Hh morphogen. Here, we show that in the Drosophila wing imaginal disc two other known Hh targets genes feed back to modulate Hh signaling. First, anterior expression of the transcriptional repressor...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (5): dev200149.
Published: 7 March 2022
... oogenesis using the model insect Drosophila melanogaster . In adult females maintained at 18°C (cold) or 29°C (warm), relative to females at the 25°C control temperature, egg production was reduced through distinct cellular mechanisms. Chronic 18°C exposure improved germline stem cell maintenance, survival...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199760.
Published: 21 February 2022
... of sample embedding. We illustrate the capacity of MuViScopy by live-imaging Drosophila melanogaster pupal development throughout metamorphosis, highlighting how internal organs are formed and multiple organ development is coordinated. We foresee that MuViScopy will open the path to better understand...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... quiescence, it remains unclear whether intrinsic and extrinsic cues coordinate to control quiescence and how cue coordination is achieved. Here, we report that Notch signaling coordinates neuroblast intrinsic temporal programs with extrinsic nutrient cues to regulate quiescence in Drosophila . When Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200110.
Published: 3 February 2022
...-established cooperation between loss of cell architecture and hyperactive signaling pathways. However, our understanding of how these different alterations interact and influence each other remains very incomplete. Using Drosophila paradigms of imaginal wing disc epithelial growth, we have monitored...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199997.
Published: 26 January 2022
...Jorge de-Carvalho; Sham Tlili; Lars Hufnagel; Timothy E. Saunders; Ivo A. Telley ABSTRACT Biological systems are highly complex, yet notably ordered structures can emerge. During syncytial stage development of the Drosophila melanogaster embryo, nuclei synchronously divide for nine cycles within...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199634.
Published: 24 January 2022
...Bonnie M. Weasner; Justin P. Kumar ABSTRACT The eye-antennal disc of Drosophila is composed of three cell layers: a columnar epithelium called the disc proper (DP); an overlying sheet of squamous cells called the peripodial epithelium (PE); and a strip of cuboidal cells that joins the other two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199866.
Published: 23 December 2021
... of the motor domain acts as a STOP. In contrast, uncoordinated mitochondrial motility was observed in CRISPR/Cas9-GSK3β non-phosphorylatable-KHCS314A Drosophila larval axons, owing to decreased kinesin 1 attachment to microtubules and/or membranes, and reduced ATPase activity. Together, we propose that GSK3β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
... the role of the Dorsal protein nuclear gradient along the dorsoventral axis in defining the graded pattern of actomyosin constriction that initiates gastrulation in early Drosophila embryos. Two complementary mechanisms for graded accumulation of mRNAs of crucial zygotic Dorsal target genes were identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev200216.
Published: 17 December 2021
...Carrie M. Spratford; Lauren M. Goins; Fangtao Chi; Juliet R. Girard; Savannah N. Macias; Vivien W. Ho; Utpal Banerjee ABSTRACT Genetic and genomic analysis in Drosophila suggests that hematopoietic progenitors likely transition into terminal fates via intermediate progenitors (IPs) with some...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199762.
Published: 15 December 2021
...Samantha A. Russell; Kaitlin M. Laws; Greg J. Bashaw ABSTRACT The Netrin receptor Frazzled/Dcc (Fra in Drosophila ) functions in diverse tissue contexts to regulate cell migration, axon guidance and cell survival. Fra signals in response to Netrin to regulate the cytoskeleton and also acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199034.
Published: 3 December 2021
... steps including image segmentation, clustering and region boundary smoothing. We illustrate the use of the pipeline using a large dataset obtained during the metamorphosis of the Drosophila pupal notum. We also adapt it to determine regions in which the time evolution of the local deformation rate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199700.
Published: 30 November 2021
...Donald F. Ready; Henry C. Chang ABSTRACT Actomyosin contraction shapes the Drosophila eye's panoramic view. The convex curvature of the retinal epithelium, organized in ∼800 close-packed ommatidia, depends upon a fourfold condensation of the retinal floor mediated by contraction of actin stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199894.
Published: 29 November 2021
... tubule. Here, we show that Drosophila CUBAM is a tripartite complex composed of Amnionless and two cubilin paralogues, Cubilin and Cubilin2, and that it is required for nephrocyte slit diaphragm (SD) dynamics. Loss of CUBAM-mediated endocytosis induces dramatic morphological changes in nephrocytes...
Includes: Supplementary data