... debate whether the Dpp gradient is required for the uniform cell proliferation observed in the wing imaginal disc. Here, we investigated how the Dpp signaling pathway regulates proliferation during wing development. By systematic manipulation of Dpp signaling we observed that it controls proliferation...

...; (B) loss of Ptc or overexpression of Hh; and (C) reduction of Dpp. For details, see Discussion. *Author for correspondence (e-mail: [email protected] ) 5 9 2001 © 2001. 2001 Dpp signaling Hh signaling Drosophila Brain Eye Optic lobe The eye...