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Keywords: Dpp
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Journal Articles
Journal: Development
Development (2017) 144 (15): 2771–2783.
Published: 01 August 2017
... morphogenetic protein Dpp in the developing fly wing and that this is necessary for developmental signaling. Inhibition of Irk channels decreases the incidence of distinct Dpp-GFP release events above baseline fluorescence while leading to a broader distribution of Dpp-GFP. Work by others in different cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1325–1335.
Published: 01 April 2015
..., such as the Dpp (a Drosophila BMP) pathway. Moreover, Lgd physically interacts with Shrub, a fundamental component of the ESCRT trafficking machinery, whose loss of function results in the activation of several signalling pathways. Here, we show that during oogenesis lgd loss of function causes ectopic activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2150–2156.
Published: 15 May 2014
... and patterning are not well understood. In the Drosophila wing imaginal disc, the morphogen Dpp guides patterning and is also required for tissue growth. In particular, it was recently reported that cell division in the disc correlates with the temporal increase in Dpp signaling. Here we mathematically model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3653–3664.
Published: 01 October 2012
... to those found when signaling through a Drosophila BMP homolog, Decapentaplegic (Dpp), is disrupted. To determine whether Irk2 plays a role in the Dpp pathway, we generated flies in which both Irk2 and Dpp functions are reduced. Irk2DN phenotypes are enhanced by decreased Dpp signaling. In wild-type flies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2170–2176.
Published: 15 June 2012
... and other tissues, and can diffuse into the pupal wing via the hemolymph. Cv-d binds to the BMPs Dpp and Gbb through its Vg domain, and to heparan sulfate proteoglycans, which are well-known for their role in BMP movement and accumulation in the wing. Cv-d acts over a long range in vivo, and does not have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 715–724.
Published: 15 February 2011
...Milán Szuperák; Sally Salah; Emily J. Meyer; Usha Nagarajan; Aissam Ikmi; Matthew C. Gibson The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied models for understanding the long-range control of tissue growth and pattern formation...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1263–1273.
Published: 15 April 2010
...-Silberberg and Schüpbach, 1993 ), to an asymmetric position with respect to the primary axis, and this specifies the orientation of the D-V axis ( Roth, 2003 ; van Eeden and St Johnston, 1999 ). Through many subsequent steps, the domain of dpp transcription is determined on the dorsal side...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1169–1177.
Published: 01 April 2009
... and pattern. Thus, the surviving cells have to undergo additional proliferation to compensate for the cell loss. The finding that apoptotic cells ectopically express dpp and wg suggested that ectopic Dpp/Wg signalling might be responsible for compensatory proliferation. We have tested this hypothesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 995–1006.
Published: 15 March 2009
... the concentration of the niche-provided self-renewal factor BMP/Dpp in metabolically active high dMyc stem cells. Genetic manipulations that impose uniform dMyc levels across the germline produce an extended Dpp signaling domain and cause uncoordinated differentiation events. We propose that dMyc-induced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4003–4013.
Published: 15 December 2008
...Gerald Schwank; Simon Restrepo; Konrad Basler Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp)regulates cell proliferation. Contrary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1039–1047.
Published: 15 March 2008
..., H. ( 2003 ). Dally regulates Dpp morphogen gradient formation in the Drosophila wing. Development 130 , 1515 -1522. Goto, S., Taniguchi, M., Muraoka, M., Toyoda, H., Sado, Y.,Kawakita, M. and Hayashi, S. ( 2001 ). UDP-sugar transporter implicated in glycosylation and processing of Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2415–2424.
Published: 01 July 2007
..., the expanded amnion and serosa anlage correlates with a broader domain of Dpp signaling as compared with the D. melanogaster embryo. Evidence is presented that this expanded signaling is due to altered expression of the sog gene. We propose that there are at least two distinct threshold readouts of Dpp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2061–2071.
Published: 01 June 2007
.... 2007 Nemo Nlk BMP Dpp Mad MH1 Smad Drosophila The Drosophila nemo ( nmo ) gene was originally found to be required for epithelial planar cell polarity during eye development( Choi and Benzer, 1994 ). Subsequent analyses have implicated nmo in patterning events during...
Journal Articles
Journal: Development
Development (2007) 134 (11): 2107–2114.
Published: 01 June 2007
... characterized the primary sequence and secondary structural requirements for the HOW response element (HRE), and show that this site is necessary and sufficient for HOW binding. Based on this analysis, we have identified the Drosophila TGFβ homolog, dpp , as a novel direct target for HOW negative regulation...
Journal Articles
Journal: Development
Development (2007) 134 (10): 1861–1871.
Published: 15 May 2007
...Julia B. Cordero; David E. Larson; Caroline R. Craig; Rebecca Hays; Ross Cagan The correct organization of cells within an epithelium is essential for proper tissue and organ morphogenesis. The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) signaling in cellular morphogenesis during...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1779–1788.
Published: 01 May 2007
...),synergistically reinforces the weak capacity of either gene, when overexpressed singly, to induce ectopic notum-like development. Whereas the Iro-C genes are activated in the notum anlage by EGFR signalling, tup is positively regulated by Dpp signalling. Our data support a model in which the EGFR and Dpp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (17): 3295–3303.
Published: 01 September 2006
...Erdem Bangi; Kristi Wharton Wing patterning in Drosophila requires a Bmp activity gradient created by two Bmp ligands, Gbb and Dpp, and two Bmp type I receptors, Sax and Tkv. Gbb provides long-range signaling, while Dpp signals preferentially to cells near its source along the anteroposterior (AP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (12): 2347–2357.
Published: 15 June 2006
...Yasuko Akiyama-Oda; Hiroki Oda The mechanism by which Decapentaplegic (Dpp) and its antagonist Short gastrulation (Sog) specify the dorsoventral pattern in Drosophila embryos has been proposed to have a common origin with the mechanism that organizes the body axis in the vertebrate embryo. However...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1485–1494.
Published: 15 April 2006
... nuclear signaling. Ectopic expression of Msk overcomes this block and disrupts patterning. Additionally,the MAPK cytoplasmic hold is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors. † Author for correspondence (e-mail: mosesk@hhmi.org ) * Present address...
Journal Articles
Journal: Development
Development (2005) 132 (20): 4587–4598.
Published: 15 October 2005
... from the R1-R6 neurons stop between two layers of glial cells in the lamina,the most superficial ganglion in the optic lobe. Although it has been suggested that the lamina glia serve as intermediate targets of R axons,little is known about the mechanisms by which these cells develop. We show that DPP...