...Endika Haro; Billy A. Watson; Jennifer M. Feenstra; Luke Tegeler; Charmaine U. Pira; Subburaman Mohan; Kerby C. Oberg Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb...

...Sho Ohta; Baolin Wang; Suzanne L. Mansour; Gary C. Schoenwolf The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how...

...Tobias Roeser; Stefan Stein; Michael Kessel ABSTRACT Studies in Xenopus laevis and zebrafish suggest a key role for β-catenin in the specification of the axis of bilateral symmetry. In these organisms, nuclear β-catenin demarcates the dorsalizing centers. We have asked whether β-catenin plays...

... expression in the marginal zone. Szl can dorsalize Xenopus embryos if expressed after the midblastula transition, strengthening the idea that zygotic expression of wnts and in particular of Xwnt8 plays a role in antagonizing dorsal signals. It also suggests that inhibiting ventralizing wnts parallels...

... that, with the exception of the dorsal most marginal zone, all regions of the early dino mutant embryo acquire more ventral fates. These alterations are already apparent before the onset of gastrulation. mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes...

...-2 ) are identified and shown to be expressed transiently during embryogenesis, first within the vegetal region of late blastulae and later in the marginal zone during gastrulation, with enrichment in the dorsal lip. Xnr s and mouse nodal function as dosedependent dorsoanterior and ventral mesoderm...

...Laura A. Lettice; Jonathan M. W. Slack ABSTRACT According to the ‘three signal model’, the regional specification of tissue type within the mesoderm of Xenopus laevis occurs in a process called ‘dorsalization’. We have studied the timing and transmission characteristics of this signal, and assessed...

... content of animal, marginal and vegetal pieces from blastulae ( Fig. 10A ). In stage 10 gastrulae there is an excess in dorsal quarters over ventral three-quarters ( Fig. 10B ), and a considerable excess in vegetal over animal halves ( Fig. 10C ). In neurulae (stage 13-19) and lozenge stages (stage 20-24...

... be solely responsible for inducing the ventral mesoderm and that dorsalization of ventral mesoderm to the level of somitic muscle might be achieved either by a very high local concentration of FGF in the dorsal region, or by the action of a second, synergistic, agent in the dorsal region. 08 04 1988...

...Chester M. Regen; Richard A. Steinhardt The discovery that lithium treatment at blastula stages can induce axis formation suggested that it might act by respecifying the cytoplasmic rearrangement-generated dorsoventral pattern, so that ventral cells behave like their dorsal counterparts. We have...

...L. Dale; J. M. W. Slack ABSTRACT We have further analysed the roles of mesoderm induction and dorsalization in the formation of a regionally specified mesoderm in early embryos of Xenopus laevis. First, we have examined the regional specificity of mesoderm induction by isolating single blastomeres...

... induction occurs in the early blastula and results from the action of vegetal pole cells on the animal hemisphere. At least two mesodermal rudiments are formed, one dorsal and one ventral. During the next interaction, which we call dorsalization , the ventral mesodermal rudiment becomes subdivided...