...-mediated α V knockdown strategy to study αV function. Although α V morphants displayed vascular defects, they also exhibited left-right body asymmetry defects affecting multiple visceral organs. This was preceded by mislocalization of dorsal forerunner cells (DFCs) and malformation of the Kupffer's vesicle...

... describe an endogenous Ca 2+ release event in the region of the KV precursors (dorsal forerunner cells, DFCs), prior to KV and cilia formation. Manipulation of Ca 2+ release to disrupt this early flux does not impact early DFC specification, but results in altered DFC migration or cohesion in the tailbud...

...Jeffrey J. Essner; Jeffrey D. Amack; Molly K. Nyholm; Erin B. Harris; H. Joseph Yost Monocilia have been proposed to establish the left-right (LR) body axis in vertebrate embryos by creating a directional fluid flow that triggers asymmetric gene expression. In zebrafish, dorsal forerunner cells...

[email protected] ; [email protected] ) 3 March 1998 28 December 1998 © 1999 by Company of Biologists 1999 Spemann organizer Nieuwkoop center Notochord Prechordal mesendoderm Dorsal forerunner cells A-P patterning bozozok Axis A series of inductive events...