... ). Mesoderm-derived PDGFRA(+) cells regulate the emergence of hematopoietic stem cells in the dorsal aorta . Nat. Cell Biol. 24 , 1211 - 1225 . 10.1038/s41556-022-00955-3 Chen , M. J. , Yokomizo , T. , Zeigler , B. M. , Dzierzak , E. and Speck , N. A. ( 2009 ). Runx1...

...Rebecca K. Schiavo; Owen J. Tamplin ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells that self-renew or differentiate to establish the entire blood hierarchy. HSPCs arise from the hemogenic endothelium of the dorsal aorta (DA) during development in a process called...

... a new mechanism contributing to FN pillar formation by focusing on cyclic expansion of adjacent dorsal aorta. Maintenance of the directional alignment of the FN pillars depends on pulsatile blood flow through the dorsal aortae. These results suggest that the FN pillars are specifically established...

...Milan Esner; Sigolène M. Meilhac; Frédéric Relaix; Jean-François Nicolas; Giulio Cossu; Margaret E. Buckingham We show that cells of the dorsal aorta, an early blood vessel, and of the myotome, the first skeletal muscle to form within the somite, derive from a common progenitor in the mouse...

...Daniel P. Szeto; Kevin J. P. Griffin; David Kimelman The recently identified zebrafish T-box gene hrT is expressed in the developing heart and in the endothelial cells forming the dorsal aorta. Orthologs of hrT are expressed in cardiovascular cells from Drosophila to mouse, suggesting...

... of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. BMP-4 and BMP-7...