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Keywords: Dnmt1
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200390.
Published: 25 May 2022
... in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. Depletion of dnmt1 resulted in decreased DNA methylation levels and impaired HSPC production. Mechanistically, we found that loss of dnmt1 induced hypomethylation of Notch genes...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (18): 3303–3314.
Published: 15 September 2017
... by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression. Our results indicate that Chk1 pathway activation overrides mitotic safeguards and uncouples neuronal differentiation from mitotic resistance. * Author for correspondence ( [email protected] ) Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2277–2286.
Published: 1 July 2009
... in embryos induces programmed cell death at the onset of gastrulation. MBD4 interacts directly with both DNMT1 and MLH1, leading to recruitment of the latter to heterochromatic sites that are coincident with DNMT1 localisation. Time-lapse microscopy of micro-irradiated mammalian cells shows that MLH1/MBD4...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3345–3356.
Published: 1 August 2005
... that conditional gene deletion of the maintenance DNA methyltransferase I (Dnmt1) in neural progenitor cells (NPCs) results in DNA hypomethylation and precocious astroglial differentiation. The developmentally regulated demethylation of astrocyte marker genes as well as genes encoding the crucial components...
Includes: Supplementary data