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1-5 of 5
Keywords: Dnmt1
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Journal Articles
Journal:
Development
Development (2022) 149 (10): dev200390.
Published: 25 May 2022
... in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. Depletion of dnmt1 resulted in decreased DNA methylation levels and impaired HSPC production. Mechanistically, we found that loss of dnmt1 induced hypomethylation of Notch genes...
Includes: Supplementary data
Journal Articles
In collection:
Chromatin & epigenetics
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, Fuyuko Shiotani, Kei-ichiro Ishiguro, Kazuyuki Ohbo, Haruhiko Koseki
Journal:
Development
Development (2021) 148 (10): dev194605.
Published: 17 May 2021
... of meiosis, especially in the adult, is not well understood. Here, we reveal that NP95 (also known as UHRF1) and DNMT1 – two essential proteins for maintenance DNA methylation – are co-expressed in spermatogonia and are necessary for meiosis in male germ cells. We find that Np95 - or Dnmt1 -deficient...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal:
Development
Development (2017) 144 (18): 3303–3314.
Published: 15 September 2017
... by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression. Our results indicate that Chk1 pathway activation overrides mitotic safeguards and uncouples neuronal differentiation from mitotic resistance. As differentiation and proliferation remain tightly regulated...
Includes: Supplementary data
Journal Articles
Alexey Ruzov, Boris Shorning, Oliver Mortusewicz, Donncha S. Dunican, Heinrich Leonhardt, Richard R. Meehan
Journal:
Development
Development (2009) 136 (13): 2277–2286.
Published: 1 July 2009
... in embryos induces programmed cell death at the onset of gastrulation. MBD4 interacts directly with both DNMT1 and MLH1, leading to recruitment of the latter to heterochromatic sites that are coincident with DNMT1 localisation. Time-lapse microscopy of micro-irradiated mammalian cells shows that MLH1/MBD4...
Includes: Multimedia, Supplementary data
Journal Articles
Guoping Fan, Keri Martinowich, Mark H. Chin, Fei He, Shaun D. Fouse, Leah Hutnick, Daisuke Hattori, Weihong Ge, Yin Shen, Hao Wu, Johanna ten Hoeve, Ke Shuai, Yi E. Sun
Journal:
Development
Development (2005) 132 (15): 3345–3356.
Published: 1 August 2005
... that conditional gene deletion of the maintenance DNA methyltransferase I (Dnmt1) in neural progenitor cells (NPCs) results in DNA hypomethylation and precocious astroglial differentiation. The developmentally regulated demethylation of astrocyte marker genes as well as genes encoding the crucial components...
Includes: Supplementary data