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Keywords: Dkk1
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Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
... knocking out the secreted WNT inhibitors active in our system, we show that DKK1 alone controls the extent and duration of patterning. The NODAL inhibitor cerberus 1 acts downstream of WNT to refine the endoderm versus mesoderm fate choice. Our EMT wave is a generic property of a bistable system with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3859–3867.
Published: 15 October 2014
... the embryonic head of the Otx2 null mutant. Expression of Dkk1 and Lhx1 , two genes that are also essential for head formation, is disrupted in the AME of the conditional Otx2 -deficient embryos. Consistent with the fact that Dkk1 is a direct target of OTX2, we showed that OTX2 can interact with the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3731–3742.
Published: 15 September 2013
... the mesenchyme itself is regulated by Wnt signaling. Nevertheless, we found that during lung initiation simultaneous overexpression of Fgf10 is not sufficient to rescue the absence of primary lung field specification in embryos overexpressing Dkk1 , a secreted inhibitor of Wnt signaling. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 667–676.
Published: 15 February 2011
...Nicolas Fossat; Vanessa Jones; Poh-Lynn Khoo; Debora Bogani; Andrea Hardy; Kirsten Steiner; Mahua Mukhopadhyay; Heiner Westphal; Patrick M. Nolan; Ruth Arkell; Patrick P. L. Tam In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3719–3729.
Published: 15 November 2008
...Sang-Wook Cha; Emmanuel Tadjuidje; Qinghua Tao; Christopher Wylie; Janet Heasman Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3731–3743.
Published: 15 November 2008
... female mice is profoundly affected by the loss of GATA4-FOG2 interaction. We have also identified the Dkk1 gene, which encodes a secreted inhibitor of canonical β-catenin signaling, as a target of GATA4-FOG2 repression in the developing ovary. The tissue-specific ablation of theβ-catenin gene in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1791–1801.
Published: 15 May 2008
...Samara L. Lewis; Poh-Lynn Khoo; R. Andrea De Young; Kirsten Steiner; Chris Wilcock; Mahua Mukhopadhyay; Heiner Westphal; Robyn V. Jamieson; Lorraine Robb; Patrick P. L. Tam Loss of Dkk1 results in ectopic WNT/β-catenin signalling activity in the anterior germ layer tissues and impairs cell movement...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4755–4764.
Published: 01 November 2005
... majority of the autopod skeletal elements. We show that FGFR1 deficiency does not affect cell proliferation. Instead, it triggers cell death and leads to alterations in expression of a number of genes involved in apoptosis and digit patterning, including increased expression of Bmp4 , Dkk1 and Alx4 , and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4819–4829.
Published: 01 October 2004
... 2 7 2004 © 2004. 2004 Mammary gland Placode Mammary bud WNT TOPGAL Dkk1 Mouse Mammary glands, like hair and teeth, are epithelial appendages that originate from the surface ectoderm and develop through epithelial–mesenchymal interactions( Hardy, 1992 ; Thesleff et al...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2543–2552.
Published: 01 June 2004
... of dickkopf 1( Dkk1 ), the secreted Wnt antagonist. Expression of Dkk1 from the doubleridge allele ranges from 35% of wild-type level in E7.0 head to <1% of wild type in E13.5 tail. doubleridge homozygotes and doubleridge/ null compound heterozygotes are viable. An allelic series combining the...