.... By knocking out the secreted WNT inhibitors active in our system, we show that DKK1 alone controls the extent and duration of patterning. The NODAL inhibitor cerberus 1 acts downstream of WNT to refine the endoderm versus mesoderm fate choice. Our EMT wave is a generic property of a bistable system...

... of the embryonic head of the Otx2 null mutant. Expression of Dkk1 and Lhx1 , two genes that are also essential for head formation, is disrupted in the AME of the conditional Otx2 -deficient embryos. Consistent with the fact that Dkk1 is a direct target of OTX2, we showed that OTX2 can interact with the H1...

... in the mesenchyme itself is regulated by Wnt signaling. Nevertheless, we found that during lung initiation simultaneous overexpression of Fgf10 is not sufficient to rescue the absence of primary lung field specification in embryos overexpressing Dkk1 , a secreted inhibitor of Wnt signaling. However, after lung...

...Nicolas Fossat; Vanessa Jones; Poh-Lynn Khoo; Debora Bogani; Andrea Hardy; Kirsten Steiner; Mahua Mukhopadhyay; Heiner Westphal; Patrick M. Nolan; Ruth Arkell; Patrick P. L. Tam In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses...

...Sang-Wook Cha; Emmanuel Tadjuidje; Qinghua Tao; Christopher Wylie; Janet Heasman Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both...

... of female mice is profoundly affected by the loss of GATA4-FOG2 interaction. We have also identified the Dkk1 gene, which encodes a secreted inhibitor of canonical β-catenin signaling, as a target of GATA4-FOG2 repression in the developing ovary. The tissue-specific ablation of theβ-catenin gene...

...Samara L. Lewis; Poh-Lynn Khoo; R. Andrea De Young; Kirsten Steiner; Chris Wilcock; Mahua Mukhopadhyay; Heiner Westphal; Robyn V. Jamieson; Lorraine Robb; Patrick P. L. Tam Loss of Dkk1 results in ectopic WNT/β-catenin signalling activity in the anterior germ layer tissues and impairs cell movement...

... of the majority of the autopod skeletal elements. We show that FGFR1 deficiency does not affect cell proliferation. Instead, it triggers cell death and leads to alterations in expression of a number of genes involved in apoptosis and digit patterning, including increased expression of Bmp4 , Dkk1 and Alx4...

... Dkk1 Mouse Mammary glands, like hair and teeth, are epithelial appendages that originate from the surface ectoderm and develop through epithelial–mesenchymal interactions( Hardy, 1992 ; Thesleff et al., 1995 ; Veltmaat et al., 2003 ). The first histological sign of mammary morphogenesis...

... of dickkopf 1( Dkk1 ), the secreted Wnt antagonist. Expression of Dkk1 from the doubleridge allele ranges from 35% of wild-type level in E7.0 head to <1% of wild type in E13.5 tail. doubleridge homozygotes and doubleridge/ null compound heterozygotes are viable. An allelic series combining the wild-type...

...Olga Kazanskaya; Andrei Glinka; Christof Niehrs ABSTRACT Dickkopf1 ( dkk1 ) encodes a secreted WNT inhibitor expressed in Spemann’s organizer, which has been implicated in head induction in Xenopus . Here we have analyzed the role of dkk1 in endomesoderm specification and neural patterning by gain...