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Keywords: Distal-less
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Journal Articles
Journal: Development
Development (2019) 146 (9): dev169367.
Published: 09 May 2019
... differentiation are still poorly understood. Using CRISPR-Cas9 we re-examine the function of Distal-less (Dll) as an activator or repressor of eyespots, a topic that remains controversial. We show that the phenotypic outcome of CRISPR mutations depends upon which specific exon is targeted. In Bicyclus anynana...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1755–1765.
Published: 01 May 2007
... correspondence (e-mail: Mekker@uottawa.ca ) 26 2 2007 © 2007. 2007 Telencephalon Diencephalon Interneuron Homeobox Enhancer Distal-less bHLH Mouse The establishment of a diversity of neuronal cell types in the central nervous system requires complex genetic regulatory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 117–127.
Published: 01 January 2006
... genitalia, the latter also requiring abdominal-A ( abd-A ), whereas Abd-B r shapes male genitalia (A9 in males). Although Abd-B r represses Abd-B m in the embryo, in at least part of the male A9 such regulation does not occur. In the male A9, some Abd-B m – r – or Abd-B r – clones activate Distal-less and...
Journal Articles
Journal: Development
Development (2005) 132 (23): 5261–5270.
Published: 01 December 2005
... contribute quantitatively to several functions are subject to intense purifying selection. * Author for correspondence (e-mail: sbcarrol@wisc.edu ) 4 10 2005 ©2005. 2005 Ultrabithorax Distal-less Limb Hox Evolution Peptide motif Trichome Abdominal tergite Postnotal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1579–1590.
Published: 01 April 2005
... cell types. * Author for correspondence (e-mail: zoltan@zfin.org ) 25 1 2005 ©2005. 2005 Adenohypophysis Anterior neural plate border Cell fate specification Cell lineage Distal-less Patched Smoothened Sonic hedgehog Ventral ectoderm Zebrafish The pituitary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (2): 371–382.
Published: 15 January 2005
...@mail.bio.tamu.edu ) * These authors contributed equally to this work 17 11 2004 ©2005. 2005 Preplacodal domain Otic placode Genetic network Paired Fibroblast growth factor forkhead distal-less msxC Pax proteins are key regulators of developmental processes including...
Journal Articles
Journal: Development
Development (2004) 131 (4): 767–774.
Published: 15 February 2004
... secreted signaling proteins that direct localized expression of transcription factors. The Drosophila homeodomain protein Distal-less is expressed in the leg primordia and required for formation of legs, but not wings. The homeodomain protein Nubbin is expressed in the wing primordia and required for...
Journal Articles
Journal: Development
Development (2003) 130 (6): 1171–1180.
Published: 15 March 2003
... differentiation of antenna-specific characteristics. Antenna-specific expression of dan and danr depends on a regulatory hierarchy involving homothorax and Distal-less , as well as cut and spineless . We propose that dan and danr are effector genes that act downstream of these genes to control differentiation of...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4371–4386.
Published: 01 October 2002
...Grace Panganiban; John L. R. Rubenstein Distal-less is the earliest known gene specifically expressed in developing insect limbs; its expression is maintained throughout limb development. The homeodomain transcription factor encoded by Distal-less is required for the elaboration of proximodistal...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3555–3561.
Published: 01 August 2002
... prominent ventral branch found in the second to fourth legs. We show here that this phenotype correlates with the loss of Distal-less and concomitant expression of Antennapedia in the limb primordium. Unlike its Drosophila counterpart, Daphnia Antennapedia represses Distal-less in Drosophila assays, and the...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1967–1974.
Published: 15 April 2002
... antenna development. The nuclear factors, Homothorax, Distal-less and Spineless, are each required for particular aspects of antennal fate. Coexpression of Homothorax, necessary for nuclear localization of its ubiquitously expressed partner Extradenticle, with Distal-less is required to establish antenna...
Journal Articles
Journal: Development
Development (2002) 129 (3): 695–704.
Published: 01 February 2002
... that bric a brac expression is activated early throughout most of the Distal-less domain in both antenna and leg and subsequently is restricted to the distal portion and into rings. Although bric a brac expression in the antenna and in all four tarsal rings of the leg requires Distal-less, only the...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4511–4521.
Published: 15 November 2001
... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation by...
Journal Articles
Journal: Development
Development (2001) 128 (14): 2803–2814.
Published: 15 July 2001
... genetic studies have revealed a developmental system for patterning appendages and identified several genes required for limb development. Among these are: extradenticle ( exd ) , homothorax ( hth ) , dachshund ( dac ), Distal-less ( Dll ) and spalt ( sal ). These limb genes have not been well studied in...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2365–2372.
Published: 15 June 2001
..., R. (1935) Book Principles of Insect Morphology . New York: McGraw-Hill). To gain insight into how variations between the antenna and the leg may have arisen, we have compared the epistatic relationships among three major proximodistal patterning genes, Distal-less , dachshund and homothorax , in the...