1-20 of 23
Keywords: Dishevelled
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 05 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev186338.
Published: 22 May 2020
...-autonomously controls protrusion formation of NC cells and Trio morphant NC cells show a blebbing phenotype. Interestingly, the Trio GEF2 domain is sufficient to rescue protrusion formation and migration of Trio morphant NC cells. We show that this domain interacts with the DEP/C-terminus of Dishevelled (DVL...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev143107.
Published: 10 April 2018
...Hyeyoon Lee; Seong-Moon Cheong; Wonhee Han; Youngmu Koo; Saet-Byeol Jo; Gun-Sik Cho; Jae-Seong Yang; Sanguk Kim; Jin-Kwan Han ABSTRACT Dishevelled (Dvl/Dsh) is a key scaffold protein that propagates Wnt signaling essential for embryogenesis and homeostasis. However, whether the antagonism of Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3429–3439.
Published: 01 October 2015
... proteins Van Gogh-like (Vangl) and Frizzled (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl). Asymmetric localization of these proteins is thought to be central to their function, and understanding the dynamics of these proteins is an important challenge in developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4354–4365.
Published: 15 November 2014
... blastomere. The ABar and EMS spindles both reorient in response to Wnt signals, but only ABar spindle reorientation is dependent on a new cell contact and on HS and SDN-1. SDN-1 transiently accumulates on the ABar surface as it contacts C, and is required for local concentration of Dishevelled (MIG-5) in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3222–3232.
Published: 15 August 2014
...Linh Thuong Vuong; Bibhash Mukhopadhyay; Kwang-Wook Choi Wingless (Wg)/Wnt signaling is fundamental in metazoan development. Armadillo (Arm)/β-catenin and Dishevelled (Dsh) are key components of Wnt signal transduction. Recent studies suggest that intracellular trafficking of Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1693–1702.
Published: 15 April 2013
... one mechanism to control core protein levels in Drosophila , and that without this regulation cellular asymmetry is compromised. Levels of Dishevelled at junctions are regulated by a Cullin-3-Diablo/Kelch ubiquitin ligase complex, the activity of which is most likely controlled by neddylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4405–4415.
Published: 01 December 2012
... output; but what might underpin this Notch regulation is not understood. Here, we show that Wnt acts via Dishevelled to inhibit Notch signalling, and that this crosstalk regulates cell-fate specification in vivo during Xenopus development. Mechanistically, Dishevelled binds and directly inhibits CSL...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2584–2593.
Published: 15 July 2012
..., only cells distal to ligand-producing cells are capable of responding. Here, we show that the asymmetric distribution of planar cell polarity (PCP) proteins correlates with this spatial restriction of Notch activation. Frizzled and Dishevelled are enriched at distal sides of each cell and hence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 1023–1033.
Published: 01 March 2012
...@mail.med.upenn.edu ) Competing interests statement The authors declare no competing financial interests. 22 12 2011 © 2012. Zebrafish Muscle specific kinase MuSK Unplugged Wnt11 Dishevelled Rab11 Recycling endosome Neuromuscular junction Planar cell polarity...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5441–5450.
Published: 15 December 2011
... experiments implicate Wnt11-like proteins in NC specification in Xenopus embryos. In support of this conclusion, modulation of β-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premigratory NC. Morpholino-mediated depletion experiments suggest that Wnt11R, a Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3297–3306.
Published: 01 August 2011
... necessary for activation of the endomesoderm GRN. If that cortical region of the egg is removed, addition of Wnt6 rescues endoderm. At a molecular level, the vegetal cortex region contains a localized concentration of Dishevelled (Dsh) protein, a transducer of the canonical Wnt pathway; however, Wnt6 mRNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3287–3296.
Published: 01 August 2011
.... , Miller J. R. , Shulman J. M. , Moon R. T. , Perrimon N. ( 1998 ). Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways . Genes Dev. 12 , 2610 - 2622 . Becker C. G. , Schweitzer J...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 2121–2131.
Published: 15 June 2009
... of dscr5 disrupted Knypek membrane localization and caused an enhanced Frizzled 7 receptor endocytosis in a Caveolin-dependent manner. Furthermore, dscr5 knockdown promoted specific Dishevelled degradation by the ubiquitin-proteosome pathway. These results reveal a functional link between Knypek...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
... frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3587–3596.
Published: 15 August 2005
...-box genes and may indicate a general functional mechanism for T-box proteins. † Author for correspondence (e-mail: vlad@imcb.a-star.edu.sg ) * These authors contributed equally to this work 9 6 2005 ©2005. 2005 T-box Cell adhesion Zebrafish Frizzled 7 Dishevelled...
Journal Articles
Journal: Development
Development (2004) 131 (24): 6195–6209.
Published: 15 December 2004
... time-lapse analysis of gastrulation, and examined both wild-type embryos and embryos in which gastrulation was disrupted by the manipulation of Dishevelled (Xdsh)signaling. Remarkably, although inhibition of Xdsh signaling disrupted both convergent extension and blastopore closure, mesendoderm...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5909–5921.
Published: 01 December 2004
...Joshua S. Waxman; Anne M. Hocking; Cristi L. Stoick; Randall T. Moon Wnt signaling pathways in vertebrates use the phosphoprotein Dishevelled(Dvl). The cellular responses to Wnt signaling may in part be modulated by Dvl-associated proteins, including Dapper (Dpr). We have cloned and characterized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2947–2956.
Published: 15 June 2004
...-catenin. Calculations show that the difference in β-catenin half-life at the animal and vegetal poles of the early embryo is sufficient to produce a difference of more than 100-fold in levels of the protein in less than 2 hours. We show that dishevelled (Dsh), a key signaling protein, is required for the...
Journal Articles
Journal: Development
Development (2003) 130 (13): 3007–3014.
Published: 01 July 2003
... cell polarisation. We find that the Strabismus protein becomes asymmetrically localised to the proximal edge of cells. In the absence of strabismus activity, the planar polarity proteins Dishevelled and Prickle are mislocalised in the cell. We show that Strabismus binds directly to Dishevelled and...