... interactions Human development Disease modeling Pluripotent stem cells European Molecular Biology Organization http://dx.doi.org/10.13039/100004410 ALTF 321-2021 Wu Tsai Neurosciences Institute, Stanford University Stanford Bio-X New York Stem Cell Foundation...

... predicting gene regulatory network behavior, improving stem cell disease modeling, dissecting the epigenetic code, reprogramming cell fate and treating diseases of gene dysregulation. In addition to CRISPR-Cas9 mutagenesis, CRISPR-Cas9 has also been used to epigenetically modify genomic regions through...

... chemically defined conditions. We also successfully induced cells with differentiation capacities similar to those of multipotent mesenchymal stromal cells (MSC-like cells) from SMs. To evaluate the usefulness of these protocols, we conducted disease modeling of fibrodysplasia ossificans progressiva (FOP...

... simple tool for exploring disease pathogenesis and underlying mechanisms. In this Spotlight article, we discuss the progress and limitations of the current 2D iPSC disease-modeling platform, as well as recent advancements in the development of human iPSC models that mimic in vivo tissues and organs...

... embryonic stem cells Disease modeling Chromosomal instability Neurogenesis DNA damage and repair CHDI Foundation 10.13039/100005725 A-9423 NYSTEM New York State Stem Cell Science 10.13039/100003194 C028128 Robertson Foundation Rockefeller University...

... the major findings and themes that emerged from the 2016 EMBOǀEMBL Symposium entitled ‘Organoids: modelling organ development and disease in 3D culture’. Disease modeling Organoids Stem cells In vitro Three dimensional The field of organoid biology is advancing rapidly. An array...

... in the generation of pluripotent stem cell- and AdSC-derived organoids, highlighting their potential for enhancing our understanding of human development. We will also explore how this new culture system allows disease modeling and gene repair for a personalized regenerative medicine approach. The mature stomach...

... of Biologists Ltd 2015 Summary: This opinion piece discusses the difficulties involved in using stem cells to study diseases of the elderly, and how these might be overcome. Disease modeling Aging Rejuvenation Introduction Age is the primary risk factor for many human pathologies...

... and in laboratories. In particular, the medical applications of human iPSCs in disease modeling and stem cell therapy have been progressing rapidly. The ability to induce cell fate conversion is attractive not only for these applications, but also for basic research fields, such as development, cancer, epigenetics...