... axon patterning in Drosophila by local modulation of Abl tyrosine kinase signaling, via direct interactions with the Abl co-factors Disabled and Trio. Here, we show that Notch-Abl axonal signaling requires both of the proteolytic cleavage events that initiate canonical Notch signaling. We further show...

... of development. Although individual components are known, the relationships among them remain unresolved. We now use FRET measurements of pathway activity, analysis of protein localization and genetic epistasis to dissect the structure of this network in Drosophila . We find that the adaptor protein Disabled...

...Jeong K. Song; Ramakrishnan Kannan; Gunter Merdes; Jaskirat Singh; Marek Mlodzik; Edward Giniger Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates. It has long been speculated that the adaptor protein Disabled (Dab), which is a key regulator...

.... Furthermore,we have found that all five mutations originally attributed to disabled are in fact alleles of nrt . These results suggest Ama/Nrt-mediated adhesion may be part of signaling networks involving the Abl tyrosine kinase in the growth cone. ‡ Author for correspondence (e-mail: [email protected]...

... by Company of Biologists 1992 Abelson tyrosine kinase Drosophila eye development muscle development expression disabled cell-cell interaction nervous system Mutations in the abl gene of Drosophila lead to devel- opmental defects that appear late in development. These include...