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Keywords: Directed differentiation
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Journal Articles
Journal: Development
Development (2019) 146 (2): dev171652.
Published: 22 January 2019
...Ana Luisa Rodrigues Toste de Carvalho; Alexandros Strikoudis; Hsiao-Yun Liu; Ya-Wen Chen; Tiago J. Dantas; Richard B. Vallee; Jorge Correia-Pinto; Hans-Willem Snoeck ABSTRACT Although strategies for directed differentiation of human pluripotent stem cells (hPSCs) into lung and airway have been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev168617.
Published: 21 November 2018
... the production of different cell types in vitro either through the recapitulation of developmental processes, often termed ‘directed differentiation’, or the forced expression of lineage-specific transcription factors. Although cells produced by both approaches are increasingly used in translational applications...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 958–962.
Published: 15 March 2017
.... A. , Kuhar , M. F. , Vallance , J. E. , Tolle , K. , Hoskins , E. E. , Kalinichenko , V. V. , Wells , S. I. , Zorn , A. M. , et al. ( 2011 ). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro . Nature   470 , 105 - 109 . 10.1038...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 1937–1947.
Published: 01 June 2015
... (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells...
Journal Articles
Journal: Development
Development (2015) 142 (1): 17–20.
Published: 01 January 2015
.... Directed differentiation Embryogenesis Embryonic stem cells Human development Pluripotent stem cells For four days in late September 2014, the beautiful venue of Wotton House, Dorking, UK, played host to the Company of Biologists' workshop ‘From Stem Cells to Human Development...
Journal Articles
Journal: Development
Series: Primer Series
Development (2014) 141 (4): 752–760.
Published: 15 February 2014
... will review how recent advances in developmental and stem cell biology have made it possible to generate complex, three-dimensional, human intestinal tissues in vitro through directed differentiation of human pluripotent stem cells. These are currently being used to study human development, genetic forms...
Journal Articles
Journal: Development
Development (2013) 140 (8): 1639–1644.
Published: 15 April 2013
... contributed equally to this work Competing interests statement The authors declare no competing financial interests. 4 2 2013 © 2013. Published by The Company of Biologists Ltd 2013 Directed differentiation Cardiomyocyte Transcription factor Mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 705–717.
Published: 15 February 2013
... ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Human pluripotent stem cells Directed differentiation Gene targeting High-throughput screening Human pluripotent stem cells (hPSCs), which...
Journal Articles
Journal: Development
Development (2013) 140 (2): 301–312.
Published: 15 January 2013
... stepwise method that represents a platform for in vitro human developmental neurobiology studies and drug screening approaches. In this study, we developed an ontogeny-recapitulating protocol for the directed differentiation of hPS cells toward the striatal fate. We show that a dual-SMAD inhibition step...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2866–2877.
Published: 15 August 2012
... financial interests. 28 5 2012 © 2012. Pluripotent stem cells Directed differentiation Extra-embryonic endoderm FGF Mouse embryo Early mammalian embryogenesis is characterized by a gradual restriction in the developmental potential of cells that constitute...
Includes: Supplementary data