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Keywords: Diffusion
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Journal Articles
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Plant development
Journal: Development
Development (2022) 149 (15): dev200510.
Published: 28 July 2022
... mutant background. Here, we propose through mathematical modeling that BRAVO confines its own expression domain to the stem-cell niche by attenuating a WOX5-dependent diffusible activator of BRAVO. This negative feedback drives WOX5 activity to be spatially restricted as well. The results show that WOX5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1621–1638.
Published: 15 April 2013
... debate for decades. Recent imaging studies and biophysical measurements have provided evidence for various morphogen transport models ranging from passive mechanisms, such as free or hindered extracellular diffusion, to cell-based dispersal by transcytosis or cytonemes. Here, we analyze these transport...
Journal Articles
Journal: Development
Development (2009) 136 (24): 4083–4088.
Published: 15 December 2009
...Yusuke Mii; Masanori Taira Secreted Frizzled-related proteins (sFRPs) are thought to negatively modulate Wnt signalling. Although Wnt proteins are thought to diffuse extracellularly and act as morphogens, little is known about the diffusibility of either Wnts or sFRPs. Here we show that Frzb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 889–900.
Published: 1 March 2006
... that operate dynamically at various times during patterning can shape a tissue pattern. 5 12 2005 © 2006. 2006 * Author for correspondence (e-mail: schaffer@cchem.berkeley.edu ) Morphogen Sonic hedgehog Diffusion Transport Modeling For decades the morphogen...
Includes: Multimedia, Supplementary data