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Keywords: Diffusion
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (3): dev202128.
Published: 12 February 2024
... there are spatial differences in Bcd diffusivity along the AP axis, with Bcd diffusing more rapidly in the posterior. We establish that such spatially varying differences in Bcd dynamics are sufficient to explain how Bcd can have a steep exponential gradient in the anterior half of the embryo and yet still have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (19): dev201559.
Published: 3 October 2023
...-in at the endogenous fgf8a locus. By combining sensitive imaging with single-molecule fluorescence correlation spectroscopy, we demonstrate that Fgf8a, which is produced at the embryonic margin, propagates by diffusion through the extracellular space and forms a graded distribution towards the animal pole. Overlaying...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (15): dev200510.
Published: 28 July 2022
... mutant background. Here, we propose through mathematical modeling that BRAVO confines its own expression domain to the stem-cell niche by attenuating a WOX5-dependent diffusible activator of BRAVO. This negative feedback drives WOX5 activity to be spatially restricted as well. The results show that WOX5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1621–1638.
Published: 15 April 2013
... debate for decades. Recent imaging studies and biophysical measurements have provided evidence for various morphogen transport models ranging from passive mechanisms, such as free or hindered extracellular diffusion, to cell-based dispersal by transcytosis or cytonemes. Here, we analyze these transport...
Journal Articles
Journal: Development
Development (2009) 136 (24): 4083–4088.
Published: 15 December 2009
...Yusuke Mii; Masanori Taira Secreted Frizzled-related proteins (sFRPs) are thought to negatively modulate Wnt signalling. Although Wnt proteins are thought to diffuse extracellularly and act as morphogens, little is known about the diffusibility of either Wnts or sFRPs. Here we show that Frzb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 889–900.
Published: 1 March 2006
... that operate dynamically at various times during patterning can shape a tissue pattern. * Author for correspondence (e-mail: schaffer@cchem.berkeley.edu ) 5 12 2005 © 2006. 2006 Morphogen Sonic hedgehog Diffusion Transport Modeling For decades the morphogen...
Includes: Multimedia, Supplementary data