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Keywords: Differentiation
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Journal Articles
Journal: Development
Development (2021) 148 (10): dev197475.
Published: 25 May 2021
.... Decline of GDNF levels in postnatal kidneys normalizes the ureteric bud and creates a permissive environment for continuation of the nephrogenic program, as demonstrated by morphologically and molecularly normal postnatal nephron progenitor self-renewal and differentiation. These results establish that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196329.
Published: 15 April 2021
.... Cells with substantively decreased H3K27 methylation differentiate into embryoid bodies, which contrasts with EZH2 null cells. PRC2 targets had varied requirements for H3K27me3, with a subset that maintained normal levels of repression in the absence of methylation. The primary cellular phenotype of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197483.
Published: 15 April 2021
... pluripotent cranial neural crest cells and differentiate with distinct developmental timing and cellular morphologies. The mechanisms that divide neural crest cells into discrete populations are not fully understood. Here, we use single-cell RNA sequencing to transcriptomically define different populations of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197608.
Published: 15 February 2021
...Angel Stanoev; Christian Schröter; Aneta Koseska ABSTRACT During mammalian development and homeostasis, cells often transition from a multilineage primed state to one of several differentiated cell types that are marked by the expression of mutually exclusive genetic markers. These observations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev183442.
Published: 15 December 2020
... evident that nuclear pore complexes and their components also have multiple transport-independent functions. In recent years, an increasing number of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell differentiation and tissue-specific processes. Here, we...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev182725.
Published: 24 August 2020
... and discuss the possible functions of circRNAs in cell differentiation and development. * These authors contributed equally to this work ‡ Author for correspondence ( irene.bozzoni@uniroma1.it ) Competing interests The authors declare no competing or financial interests. © 2020...
Journal Articles
Journal: Development
Development (2020) 147 (15): dev183384.
Published: 14 August 2020
...Lale Evsen; Xiaojun Li; Shuran Zhang; Sharjil Razin; Angelika Doetzlhofer ABSTRACT The evolutionarily conserved lethal-7 ( let-7 ) microRNAs (miRNAs) are well-known activators of proliferative quiescence and terminal differentiation. However, in the murine auditory organ, let-7g overexpression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev189712.
Published: 24 July 2020
...Mario Ledesma-Terrón; Nuria Peralta-Cañadas; David G. Míguez ABSTRACT Radial glial progenitors in the mammalian developing neocortex have been shown to follow a deterministic differentiation program restricted to an asymmetric-only mode of division. This feature seems incompatible with their well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
..., once specified, further mTEC development is NOTCH independent. In addition, we demonstrate that persistent NOTCH activity favors maintenance of undifferentiated TEPCs at the expense of cTEC differentiation. Finally, we uncover a cross-regulatory relationship between NOTCH and FOXN1, a master regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev180067.
Published: 28 May 2020
... decision Differentiation Images were captured using a Zeiss Axioplan 2 manual compound microscope with a Zeiss Axiocam HRc camera and then analyzed for cell number quantification. Anti-Fezf1 and anti-Nkx2.1 ( Kurrasch et al., 2007 ) immunolabeling of adjacent sections was used to mark the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev175596.
Published: 28 May 2020
... tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation. Summary: This Review discusses our current understanding of how the extracellular matrix helps guide developing tissues by influencing cell adhesion, migration, shape and...
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
...Zhen Shi; Cindy Lim; Vuong Tran; Kairong Cui; Keji Zhao; Xin Chen ABSTRACT The Drosophila male germline stem cell (GSC) lineage provides a great model to understand stem cell maintenance, proliferation, differentiation and dedifferentiation. Here, we use the Drosophila GSC lineage to systematically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184655.
Published: 12 April 2020
... germline led to reduction of the undifferentiated spermatogonial population and a block in transition to the differentiating state. Collectively, these findings demonstrate a key role of the RBP system in regulation of the spermatogenic lineage and may provide clues about the influence of RBPs on the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181552.
Published: 17 February 2020
... essential role of cell interactions with laminin for lactogenic differentiation. * Present address: Institut de Recherche Servier, F-78290 Croissy, France. ‡ Present address: Centre de Recherche des Cordeliers, INSERM, F-75006 Paris, France. § Present address: Faculty of Medicine, Paris...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev183129.
Published: 15 January 2020
... development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both...
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181966.
Published: 03 January 2020
... chromatin across ISC differentiation. We find that open chromatin regions (OCRs) can be defined as broadly permissive or dynamic in a locus-specific manner, with dynamic OCRs found primarily in loci consistent with distal enhancers. By integrating gene expression with chromatin accessibility at...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2019) 146 (20): dev177428.
Published: 23 October 2019
... composed of multiciliated, goblet, club and basal cells, ensures proper mucociliary function and can regenerate in response to assaults. In chronic airway diseases, defective repair leads to tissue remodeling. Delineating key drivers of differentiation dynamics can help understand how normal or...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178335.
Published: 17 October 2019
... transcriptional complex with the androgen receptor to regulate target genes. Taken together, our results indicate that cholesterol metabolism plays a crucial role in GCT differentiation through autophagy. * Author for correspondence ( junichi.iwata@uth.tmc.edu ) Competing interests The authors declare...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev167106.
Published: 16 September 2019
... Development at a Glance article describes the core Hippo pathway, its regulation and the roles it plays in animal development. Cell fate Differentiation Growth Hippo pathway Morphogenesis YAP The Hippo pathway was identified using Drosophila genetic mosaic screens for genes that regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev172387.
Published: 10 July 2019
... discrete physiological identities. Here, from a forward genetic screen using zebrafish, we report the discovery that transcription factor AP-2 alpha ( tfap2a ) coordinates a gene regulatory network that activates the terminal differentiation program of distal segments in the pronephros. We found that...
Includes: Supplementary data