[email protected] ) 5 12 2006 © 2007. 2007 Pattern formation Cell-type specification Sporulation Encystation Adenylyl cyclase G Dictyostelium discoideum Encystation and sporulation are common life-cycle transitions that allow protists, fungi and lower plants to survive nutrient...

... and they also provide a better understanding of the mechanism whereby DIF directs cell type divergence. † Author for correspondence (e-mail: [email protected] ) 25 11 2002 © 2003. 2003 STAT proteins DIF Dictyostelium discoideum prestalk differentiation When...

... for correspondence (e-mail: [email protected] ) 15 5 2002 © 2002. 2002 Counting factor Cell population size Dictyostelium discoideum Little is known about the regulation of tissue size, despite it being a significant problem in both agriculture and medicine ( Day and Lawrence...

...Timothy R. Varney; Hoa Ho; Chere’ Petty; Daphne D. Blumberg The cellular slime mold, Dictyostelium discoideum is a non-metazoan organism, yet we now demonstrate that a disintegrin domain-containing protein, the product of the ampA gene, plays a role in cell type specification. Disintegrin domain...

... of development in the simple eukaryote Dictyostelium discoideum is an aggregative transition from a unicellular to a multicellular phase. Using genome-wide transcriptional analysis we show that this transition is accompanied by a dramatic change in the expression of more than 25% of the genes in the genome. We...

...-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase...

... in Dictyostelium discoideum are known to depend on PKA activity. Cells in which the receptor-coupled adenylyl cyclase gene, acaA , is genetically inactivated grow well but are unable to develop. Surprisingly, acaA − mutant cells can be rescued by developing them in mixtures with wild-type cells, suggesting...

.... * Both authors contributed equally to this work ‡ Author for correspondence (e-mail: [email protected] ) 13 5 1999 5 7 1999 © 1999 by Company of Biologists 1999 Dictyostelium discoideum STAT Tyrosine phosphorylation Receptor signaling Cell-type differentiation...

... of Biologists 1998 Dictyostelium discoideum dtfA Cell adhesion Cell sorting Cell surface protein Formation of the Dictyostelium fruiting body requires the coordination of cellular differentiation and movement. Starvation triggers pulsatile cAMP signalling, which leads to aggregation...

.... D. ( 1992 ). Overexpression of Dd PK2 protein kinase causes rapid development and affects the intracellular cAMP pathway of Dictyostelium discoideum . Development 115 , 785 – 790 . 10.1242/dev.115.3.785 Araki , T. and Maeda , Y. ( 1995 ). Cell-cycle progression during...

... . 215 , 403 – 410 . 10.1016/S0022-2836(05)80360-2 Berks , M. and Kay , R. R. ( 1990 ). Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum . Development 110 , 977 – 984 . 10.1242/dev.110.3.977 Birkenmeier...

...Akiko A. Oohata; Manabu Nakagawa; Masao Tasaka; Shigeru Fujii ABSTRACT In Dictyostelium discoideum strain V12M2, at a very low cell density (∼10 2 cells/cm 2 ), most amoebae differentiate into prespore cells in a salt solution containing cAMP if an adequately diluted conditioned medium (CM...

...: a family of molecular switches and clocks . Phil. Trans. R. Soc. Lond. B, Biol. Sci . 349 , 283 – 289 . 10.1098/rstb.1995.0114 Brenner , M. and Thoms , S. D. ( 1984 ). Caffeine blocks activation of cyclic AMP synthesis in Dictyostelium discoideum . Dev. Biol . 101 , 136 – 146...

... by the forward movement of cells located in the anterior of the prespore zone. * Present address: Dept of Pharmacology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QJ, UK 27 11 1995 © 1996 by Company of Biologists 1996 Dictyostelium discoideum basal disc ecmA...

...Dirk Dormann; Florian Siegert; Cornelis J. Weijer ABSTRACT Co-ordinated cell movement of tens of thousands of cells and periodic signals characterise the multicellular development of the cellular slime mould Dictyostelium discoideum . We investigated cell movement by analysing timelapse video...

..., indicating that cAR3 may have substituted for cAR1 in car1 − cell lines. * Author for correspondence 18 04 1994 © 1994 by Company of Biologists 1994 Dictyostelium discoideum cAMP receptor plasticity gene disruption developmental gene expression adaptation During...

...Jo Anne Powell-Coffman; Richard A. Firtel ABSTRACT While Dictyostelium discoideum has been studied as a developmental system for decades, and many regulatory proteins have been cloned, the molecular mechanisms of cell-type-specific gene expression are poorly understood. In this paper we...

...Toshinori Ozaki; Hajime Nakao; Hidefumi Orii; Takahiro Morio; Ikuo Takeuchi; Masao Tasaka The Dp87 is a novel prespore specific gene of Dictyostelium discoideum which has a long open reading frame of 555 amino acids. The entire amino acid sequence had low but significant homology to the spore coat...

...Anand Chandrasekhar; Herbert L. Ennis; David R. Soll ABSTRACT When developing cultures of Dictyostelium discoideum are disaggregated at any time prior to cell wall formation and challenged to reinitiate development, amoebae will progress through the original sequence of morpho-genetic stages...

.... These results suggest that cell differentiation could be brought about in normal development by the localized action of cAMP and DIF-1. * Author for correspondence 29 08 1990 © 1990 by Company of Biologists 1990 Dictyostelium discoideum DIF-1 cAMP adenosine ammonia cell...