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Keywords: Dictyostelium
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Journal Articles
Journal: Development
Development (2019) 146 (12): dev174268.
Published: 2 May 2019
.... The consequences of spontaneous DNA damage during development are not clear. Here, we define an approach to determine the effects of DNA damage on cell fate choice. Using single cell transcriptomics, we identified a subpopulation of Dictyostelium cells experiencing spontaneous DNA damage. Damaged cells displayed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev174268.
Published: 2 May 2019
.... The consequences of spontaneous DNA damage during development are not clear. Here, we define an approach to determine the effects of DNA damage on cell fate choice. Using single cell transcriptomics, we identified a subpopulation of Dictyostelium cells experiencing spontaneous DNA damage. Damaged cells displayed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173740.
Published: 8 April 2019
... little understanding of the processes that allow cells to become different. One of the clearest examples of developmental self-organisation is shown by Dictyostelium , with cells segregating into two major fates, stalk and spore, within multicellular aggregates. To characterise the gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173740.
Published: 8 April 2019
... little understanding of the processes that allow cells to become different. One of the clearest examples of developmental self-organisation is shown by Dictyostelium , with cells segregating into two major fates, stalk and spore, within multicellular aggregates. To characterise the gene expression...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Series: Primer Series
Development (2011) 138 (3): 387–396.
Published: 1 February 2011
...Pauline Schaap Dictyostelium discoideum belongs to a group of multicellular life forms that can also exist for long periods as single cells. This ability to shift between uni- and multicellularity makes the group ideal for studying the genetic changes that occurred at the crossroads between uni...
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (4): 579–584.
Published: 15 February 2010
... ) Competing interests statement 15 12 2009 © 2010. Dictyostelium Immediate-early response Live cell imaging Transcription The transcriptional response to extracellular signals is integral to cellular choices of proliferation, stress response and differentiation. Cells...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3093–3101.
Published: 15 September 2008
...Yoko Yamada; Hong Yu Wang; Masashi Fukuzawa; Geoffrey J. Barton; Jeffrey G. Williams CudA, a nuclear protein required for Dictyostelium prespore-specific gene expression, binds in vivo to the promoter of the cotC prespore gene. A 14 nucleotide region of the cotC promoter binds CudA in vitro...
Journal Articles
Journal: Development
Development (2008) 135 (9): 1635–1645.
Published: 1 May 2008
...Thomas Keller; Christopher R. L. Thompson One poorly understood mechanism of developmental patterning involves the intermingled differentiation of different cell types that then sort out to generate pattern. Examples of this are known in nematodes and vertebrates, and in Dictyostelium...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (18): 3349–3358.
Published: 15 September 2007
...Christopher M. West; Hanke van der Wel; Zhuo A. Wang Development in multicellular organisms is subject to both environmental and internal signals. In Dictyostelium , starvation induces amoebae to form migratory slugs that translocate from subterranean areas to exposed sites, where they culminate...
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (3): 449–458.
Published: 1 February 2006
...Eryong Huang; Simone L. Blagg; Thomas Keller; Mariko Katoh; Gad Shaulsky; Christopher R. L. Thompson The signalling molecule DIF-1 is required for normal cell fate choice and patterning in Dictyostelium . To understand how these developmental processes are regulated will require knowledge of how...
Journal Articles
Journal: Development
Development (2006) 133 (3): 439–448.
Published: 1 February 2006
... and that, by binding to the ecmA promoter at the -510 site, DimB represses ecmA gene transcription. How then is DimB activated by DIF-1? Dd-STATc provides a precedent for DIF-1 induced nuclear accumulation of a Dictyostelium protein. However, in contrast to the STAT proteins, where there is a paradigm...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4555–4565.
Published: 15 September 2004
...Christina Schilde; Tsuyoshi Araki; Hazel Williams; Adrian Harwood; Jeffrey G. Williams Glycogen synthase kinase 3 (GSK3) is a central regulator of metazoan development and the Dictyostelium GSK3 homologue, GskA, also controls cellular differentiation. The originally derived gskA -null mutant...
Journal Articles
Journal: Development
Development (2004) 131 (3): 513–523.
Published: 1 February 2004
...Christopher R. L. Thompson; Qing Fu; Caroline Buhay; Robert R. Kay; Gad Shaulsky The intermingled differentiation and sorting out of Dictyostelium prestalk-O and prespore cells requires the diffusible signaling molecule DIF-1, and provides an example of a spatial information-independent patterning...
Journal Articles