.... In contrast, much less is known about the eight type II neuroblasts in each brain lobe. Larval type II neuroblasts undergo a temporal transcription factor cascade ( Syed et al., 2017 ), and, similarly, the shorter larval INP lineages undergo a three-factor temporal transcription cascade of Dichaete, Grh...

.... SoxN is necessary and sufficient to cell-autonomously direct the expression of svb . The closely related protein Dichaete is co-regulated with SoxN and has a partially redundant function in the activation of svb expression. In addition, we show that SoxN and Dichaete function upstream of Wg...

... formation is masked by a functional redundancy with Dichaete, a second Sox protein whose expression partially overlaps that of SoxNeuro. Genetic interactions of SoxNeuro and the dorsoventral patterning genes ventral nerve chord defective and intermediate neuroblasts defective underlie ventral...

... in the developing CNS; in vertebrates there are three ( Sox1, Sox2 and Sox3 ) and in Drosophila there are two ( SoxNeuro and Dichaete) . It has been suggested there may be a degree of functional redundancy in Sox function during CNS development. We describe the CNS phenotype of a null mutation in the Drosophila...

... dorsoventral domains to acquire distinct fates. These genes include the evolutionarily conserved transcription factors ventral nerve cord defective and intermediate neuroblasts defective , as well as the Drosophila EGF receptor . We show that the Sox-domain-containing gene Dichaete/fish - hook also plays...

... to the dominant wing mutation Dichaete . Homozygous deletions of the Sox70D gene and recessive lethal Dichaete alleles have a variable embryonic segmentation phenotype. Dichaete is expressed in early embryos in a dynamic pattern reminiscent of gap and pair-rule genes and is required for the appropriate expression...