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Keywords: Diabetes
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Journal Articles
Journal: Development
Development (2020) 147 (18): dev192567.
Published: 17 September 2020
... by The Company of Biologists Ltd 2020 Summary: This short Spotlight summarizes the current state of pre-clinical and clinical research using pluripotent stem cells for regenerative therapy, and the influence of developmental biology-inspired approaches. Cardiomyopathy Diabetes Parkinson's disease...
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (12): dev189977.
Published: 22 June 2020
...., L.S. Funding This work was supported by the American Diabetes Association (1-18-PDF-107 to D.S.L.) and the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health (R01 DK118155 to P.G. and L.S.; R01 DK082590 to L.S.). Deposited in PMC for release...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev165480.
Published: 15 August 2018
... models of human pancreas development, will be of further use for understanding the mechanisms by which an ever expanding number of genes predispose to diabetes. It also provides a reference to assess the quality of protocols and pancreatic cells produced in vitro from hPSCs. Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2873–2888.
Published: 15 August 2017
... to underlie pancreas development, from induction and lineage formation to morphogenesis and organogenesis. Elucidating such principles will help to identify novel candidate disease genes and unravel the pathogenesis of pancreas-related diseases, such as diabetes, pancreatitis and cancer...
Journal Articles
Journal: Development
Development (2017) 144 (13): 2402–2414.
Published: 01 July 2017
... effectors are required in the first two weeks of life for the morphogenesis, maturation and function of pancreatic islets in mice. Islet Pancreas Mtor Postnatal Diabetes Mouse Although making up only about 1-2% of total pancreatic mass, the endocrine pancreas is part of a vital system...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 858–870.
Published: 01 March 2015
... show that BICC1 functions downstream of ONECUT1 in the pathway controlling both NEUROG3 + endocrine cell production and ductal morphogenesis, and suggest a new candidate gene for syndromes associating kidney dysplasia with pancreatic disorders, including diabetes. Onecut1 KO embryos also develop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4452–4462.
Published: 01 November 2013
...Chiara Greggio; Filippo De Franceschi; Manuel Figueiredo-Larsen; Samy Gobaa; Adrian Ranga; Henrik Semb; Matthias Lutolf; Anne Grapin-Botton In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2669–2679.
Published: 01 July 2013
... diabetes, we show that hnf1ba plays essential roles in regulating β-cell number and pancreas specification, distinct from its function in regulating pancreas size and liver specification, respectively. By combining Hnf1ba partial loss of function with conditional loss of Wnt signaling, we uncover a crucial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (19): 3205–3213.
Published: 01 October 2010
... replication and suggests novel approaches for regenerative therapy to treat diabetes. Here we use an in vivo pulse-chase labeling assay to investigate the replication dynamics of adult mouse beta cells. We find that replicated beta cells are able to re-enter the cell division cycle shortly after mitosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2365–2375.
Published: 15 May 2005
.... Their eyes were smaller and bulged less than Tsc2 mutant eyes (compare Fig. 4M,N ), revealing a tissue-autonomous effect of path on the Tsc2 phenotype. Insulin signalling Drosophila Cancer TOR Diabetes Nutrition SLC36 Overall, we conclude that the recessive phenotypes associated...
Includes: Supplementary data