...Ping Wu; Ting-Xin Jiang; Mingxing Lei; Chih-Kuan Chen; Shu-Man Hsieh Li; Randall B. Widelitz; Cheng-Ming Chuong ABSTRACT How dermis maintains tissue homeostasis in cyclic growth and wounding is a fundamental unsolved question. Here, we study how dermal components of feather follicles undergo...

... follicle placodes. In the absence of dermal Wnt signaling/β-catenin activity, patterned upregulation of epidermal β-catenin activity and Edar expression are absent. Conversely, forced activation of β-catenin signaling leads to the formation of thickened dermis, enlarged epidermal placodes and dermal...

... expression profile of EF epidermis was most similar to that of anagen epidermis, consistent with activation of β-catenin signalling. By contrast, adult dermis with ectopic hair follicles more closely resembled neonatal dermis than adult telogen or anagen dermis. In particular, genes associated with mitosis...

... both mitotic myoblasts and dermis. To examine whether spindle orientations influence fate segregation, early planar divisions were randomized and/or shifted to a perpendicular orientation by interfering with LGN function or by overexpressing inscuteable. Clones derived from single transfected cells...

... been proposed to inhibit skin appendage formation. We show that the function of specific BMPs during feather development is more complex. BMP2 and BMP7 , which are expressed in both the epidermis and the dermis, are involved in an antagonistic fashion in regulating the formation of dermal condensations...

...Jennifer Ohtola; John Myers; Batool Akhtar-Zaidi; Diana Zuzindlak; Pooja Sandesara; Karen Yeh; Susan Mackem; Radhika Atit The dermis promotes the development and maintains the functional components of skin, such as hair follicles, sweat glands, nerves and blood vessels. The dermis is also crucial...

... to the mediolateral extent of the epithelium,N-cadherin protein is inherited by both daughter cells. Prior to dermomyotome dissociation into dermis and muscle progenitors, when mitoses become perpendicularly oriented, N-cadherin remains associated only with the apical cell located in apposition to the myotome...

... of the ventral pteryla, midventral apterium and amnion. The embryonic proximal somatopleural mesoderm is determined to form a feather-forming dermis at 2 days of incubation (E2), while the embryonic distal and the extra-embryonic somatopleure remain open to determination. We found a progressive, lateral...

...Raz Ben-Yair; Nitza Kahane; Chaya Kalcheim We have previously shown that overall growth of the myotome in the mediolateral direction occurs in a coherent and uniform pattern. We asked whether development of the dermomyotome and resultant dermis follow a similar pattern or are, alternatively...

...Isabel Olivera-Martinez; Sylvain Missier; Sandrine Fraboulet; Jacques Thélu; Danielle Dhouailly The chick dorsal feather-forming dermis originates from the dorsomedial somite and its formation depends primarily on Wnt1 from the dorsal neural tube. We investigate further the origin...

...Isabel Olivera-Martinez; Monique Coltey; Danielle Dhouailly; Olivier Pourquié ABSTRACT Somites are transient mesodermal structures giving rise to all skeletal muscles of the body, the axial skeleton and the dermis of the back. Somites arise from successive segmentation of the presomitic mesoderm...

...Denis Houzelstein; Yvonnick Chéraud; Gwenola Auda-Boucher; Josiane Fontaine-Pérus; Benoît Robert ABSTRACT Experimental manipulation in birds has shown that trunk dermis has a double origin: dorsally, it derives from the somite dermomyotome, while ventrally, it is formed by the somatopleure. Taking...

...Gilat Brill; Nitza Kahane; Chana Carmeli; David von Schack; Yves-Alain Barde; Chaya Kalcheim ABSTRACT Development of the somite-derived dermatome involves conversion of the epithelial dermatome progenitors into mesenchymal cells of the dermis. In chick embryos, neural tube-derived signals...

... dermis blood vessels cutaneous nerves The innervation of a vertebrate limb consists of a set of mixed nerve trunks from which two main sets of branches diverge: those that go to muscles and those that go to the skin. We have previously examined the role of muscles in controlling routes of nerve...

... time in the wild-type explants was considerably longer in the adult than at larval stages. melanophore periodic albino Xenopus laevis mutation epidermis dermis pigmentation Table 1. Incidence of melanophore differentiation in vitro We have previously succeeded...