.../ Summary:   Drosophila spermathecal secretory lineage uses different strengths of Notch signaling that are activated by different ligand use and regulated by different endocytic mechanisms. Notch signaling strength Asymmetric Notch activation Numb Rab5 Deltex University of Connecticut...

... between the two proteins. Notch endocytosis in the absence of Crumbs results in the activation of the ligand-independent, Deltex-dependent Notch signalling pathway, and does not require the ligands Delta and Serrate or γ-secretase activity. This function of Crumbs is not due to general defects...

...Kazuya Hori; Maggy Fostier; Mikiko Ito; Takashi J. Fuwa; Masahiro J. Go; Hideyuki Okano; Martin Baron; Kenji Matsuno Notch (N) signaling is an evolutionarily conserved mechanism that regulates many cell-fate decisions. deltex ( dx ) encodes an E3-ubiquitin ligase that binds to the intracellular...

...Kenji Matsuno; Mikiko Ito; Kazuya Hori; Fumiyasu Miyashita; Satoshi Suzuki; Noriyuki Kishi; Spyros Artavanis-Tsakonas; Hideyuki Okano The Notch pathway is an evolutionarily conserved signaling mechanism that is essential for cell-cell interactions. The Drosophila deltex gene regulates Notch...

...Kenji Matsuno; Robert J. Diederich; Masahiro J. Go; Christine M. Blaumueller; Spyros Artavanis-Tsakonas ABSTRACT We present a molecular and genetic analysis which elucidates the role of deltex in the Notch signaling pathway. Using the yeast ‘interaction trap’ assay, we define the protein regions...

...Robert J. Diederich; Kenji Matsuno; Huey Hing; Spyros Artavanis-Tsakonas ABSTRACT Genetic data from Drosophila have suggested a functional relationship between the novel cytoplasmic protein encoded by the deltex locus and the transmembrane receptor encoded by Notch . We have demonstrated a direct...