... activity is reduced, quiescence is delayed or altogether bypassed, with some neuroblasts dividing continuously during the embryonic-to-larval transition. During embryogenesis before quiescence, neuroblasts express Notch and the Notch ligand Delta. After division, Delta is partitioned to adjacent GMC...

...Weronika Fic; Celia Faria; Daniel St Johnston ABSTRACT The timing of Drosophila egg chamber development is controlled by a germline Delta signal that activates Notch in the follicle cells to induce them to cease proliferation and differentiate. Here, we report that follicle cells lacking the RNA...

..., or via peripheral induction, whereby Delta is produced by a specific cell. When one mechanism is perturbed due to mutations, developmental defects or environmental stress, the remaining mechanism ensures that the niche is formed, perhaps abnormally, but still functional. This guarantees that the germline...

...Dan O. Mellott; Jordan Thisdelle; Robert D. Burke We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation, neural progenitors enter S phase coincident with expression of Sp-SoxC. We used a BAC containing GFP knocked into the Sp-SoxC locus to label...

...), but the individual cells drift out of synchrony when Delta/Notch signalling fails, causing gross anatomical defects. We and others have suggested that this is because synchrony is maintained by pulses of Notch activation, delivered cyclically by each cell to its neighbours, that serve to adjust or reset the phase...

...David W. M. Tan; Kim B. Jensen; Matthew W. B. Trotter; John T. Connelly; Simon Broad; Fiona M. Watt Human epidermal stem cells express high levels of β1 integrins, delta-like 1 (DLL1) and the EGFR antagonist LRIG1. However, there is cell-to-cell variation in the relative abundance of DLL1 and LRIG1...

...Pau Formosa-Jordan; Marta Ibañes; Saúl Ares; José María Frade Signaling mediated by the Delta/Notch system controls the process of lateral inhibition, known to regulate neurogenesis in metazoans. Lateral inhibition takes place in equivalence groups formed by cells having equal capacity...

...-cell-autonomously by upregulating Delta expression and Notch signalling. Reduction in Cdk-dependent multisite phosphorylation of Ngn2 enhances its promoter binding affinity. This leads specifically to an increase in neuronal differentiation without an apparent increase in progenitor maintenance via...

...Taro Mito; Yohei Shinmyo; Kazuki Kurita; Taro Nakamura; Hideyo Ohuchi; Sumihare Noji Delta/Notch signaling controls a wide spectrum of developmental processes, including body and leg segmentation in arthropods. The various functions of Delta/Notch signaling vary among species. For instance...

...Amanda T. Pickup; Liang Ming; Howard D. Lipshitz The induction of cone cells in the Drosophila larval eye disc by the determined R1/R6 photoreceptor precursor cells requires integration of the Delta-Notch and EGF receptor signaling pathways with the activity of the Lozenge transcription factor...

... to recapitulate the demonstrable function of full-length LvNumb. Experiments show that LvNumb requires an active Notch signal to function during NSM specification and that LvNumb functions in the cells responding to Delta and not in the cells presenting the Delta ligand. Furthermore, injection of mRNA encoding...

... in Notch signaling. P -element transformation of w 1118 flies was performed according to standard methods in our laboratory or by Genetic Services (Sudbury, MA). * Author for correspondence (e-mail: jaf@mail.utexas.edu ) 10 1 2008 © 2008. 2008 Notch Delta Epsin...

... Neural patterning Nodal Delta Notch FGF MEK ERK The central nervous system (CNS) of the Ciona intestinalis larva is remarkably similar in overall organisation to, but much simpler than, its vertebrate counterpart. It consists of an anterior sensory vesicle, followed by a narrow neck...

... involvement of Delta-Notch signaling in segmentation. Here, we report that, in the spider Achaearanea tepidariorum , the same signaling pathway exerts a different function in the presumptive caudal region before initiation of segmentation. In the developing spider embryo, the growth zone becomes...

... for correspondence (e-mail: n.daudet@ucl.ac.uk ) * These authors contributed equally to this work 26 3 2007 © 2007. 2007 Notch signalling Serrate Delta Chick embryo Inner ear Otic placode Neuroblasts Hair cell Lateral inhibition Lateral induction The vertebrate inner ear...

... levels of Notch pathway activation, resulting from a germline Delta ligand signal, induce polar cells. Here we show that low Notch activation levels,originating from Delta expressed in the polar follicle cells, are required for stalk formation. The metalloprotease Kuzbanian-like, which cleaves...

... anterior LG. Pros expression is specifically reduced in fng mutants, and is blocked by antagonism of the N pathway. The N ligand Delta (Dl), which is expressed by a subset of neurons, cooperates with Fng for N signaling in the anterior LG, leading to subtype-specific expression of Pros. Furthermore...

... evidence that during early development of the sea urchin embryo, NLK is expressed in the mesodermal precursors in response to Notch signalling and directs their fate by downregulating TCF. The expression pattern of nlk is strikingly similar to that of Delta and the two genes regulate the expression of each...

... are required for localised expression of Delta2 , which encodes a divergent form of Delta ligand. Using four distinct reagents to inhibit Delta2/Notch signals, we showed that Delta2 signalling from A-line cells, which activates the Notch/Su(H) pathway in adjacent B-line cells, is required for specification...

... ) * Present address: Nakagawa Initiative Research Unit, RIKEN, 2-1 Hirosawa,Wako, Saitama 351-0198, Japan 7 4 2005 ©2005. 2005 Wnt retina progenitor cells stem cells proneural gene Notch Delta differentiation cell cycle In the vertebrate retina, a single progenitor cell...