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Keywords: Delamination
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Journal Articles
Journal: Development
Development (2021) 148 (4): dev195404.
Published: 18 February 2021
... leucine zipper tumor suppressor 1 gene ( Lzts1 ), the expression of which is also activated by HoxB4 and HoxB9. Gain- and loss-of-function experiments showed that Lzts1, which is expressed endogenously in the IZ, controls neuronal delamination. These data collectively indicate that HoxB genes have a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
... that MMP14 is required for NC delamination. Interestingly, this role is independent of its cytoplasmic tail and of its catalytic activity. Our in vivo data indicate that, in addition to being a late pro-invasive factor, MMP14 is also likely to be an early player, owing to its role in EMT. Full...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4279–4284.
Published: 15 November 2014
..., here we show a non-cell-autonomous role for RTK-Ras signaling in the delamination of a neuroblast from an epithelial organ. The C. elegans renal-like excretory organ is initially composed of three unicellular epithelial tubes, namely the canal, duct and G1 pore cells; however, the G1 cell later...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1447–1456.
Published: 15 April 2012
... in culture. Grg3 knockout explants displayed a drastic decrease in the differentiation of all endocrine cell types owing to defects in the delamination of early endocrine progenitors from the trunk epithelium. We find that Grg3 normally suppresses E-cadherin gene expression, thereby allowing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1717–1726.
Published: 15 May 2009
... neurons does not seem to result from a defect in NCC specification as all the usual markers, with the exception of Msx1 , are expressed in the dorsal caudal-most NT as early as E4/HH24. However, Bmp4-Wnt1 signaling, which triggers trunk NCC delamination, is impaired in this region due to persistence of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4141–4145.
Published: 01 December 2007
...Anthony Graham; Aida Blentic; Sandra Duque; Jo Begbie Neurogenic placodes are specialized regions of embryonic ectoderm that generate the majority of the neurons of the cranial sensory ganglia. Here we examine in chick the mechanism underlying the delamination of cells from the epibranchial...