...Claudia Linker; Claudio D. Stern A dominant molecular explanation for neural induction is the `default model', which proposes that the ectoderm is pre-programmed towards a neural fate, but is normally inhibited by endogenous BMPs. Although there is strong evidence favouring this in Xenopus , data...

...-mail: [email protected] or [email protected] ) † Present address: Millennium Nucleus on Integrative Neurosciences, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, PO Box 70079, Santiago 7, Chile 14 4 2004 © 2004. 2004 Zebrafish Default model Neural...

..., Chordin and Follistatin,which are secreted from the organizer region that differentiates into axial mesoderm. Initially, neural-inducing signals from the organizer are thought to act in an instructive manner. They can, however, also bind directly to BMP proteins. This leads to the `default model...