... . 10.1038/nm.3314 Rodriguez , E. , Chevalier , J. , Olsen , J. , Ansbøl , J. , Kapousidou , V. , Zuo , Z. , Svenning , S. , Loefke , C. , Koemeda , S. , Drozdowskyj , P. S. et al. ( 2020 ). Autophagy mediates temporary reprogramming and dedifferentiation...

... undergo a multipotency switch, they do not make a significant contribution to acinar regeneration. Intriguingly, more than 80% of regenerated acini derive from differentiated cells, including myoepithelial and ductal cells, that appear to dedifferentiate to a progenitor-like state before re...

... relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid cell and vascular pericyte populations in the neonatal testis...

... to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential...

...Karina Geurtzen; Franziska Knopf; Daniel Wehner; Leonie F. A. Huitema; Stefan Schulte-Merker; Gilbert Weidinger Zebrafish have an unlimited capacity to regenerate bone after fin amputation. In this process, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus represent...

... maintenance and reprogramming during normal development, regeneration and oncogenic transformation. Retinal development Dedifferentiation Pupal eye Transdifferentiation Pigment cell Drosophila Terminal differentiation involves a complex and coordinated sequence of events through...

.... The blastema is thought to originate from either stem (or progenitor) cells or differentiated cells of various tissues that undergo dedifferentiation. Here, we investigate the origin of cells that contribute to the regeneration of zebrafish caudal fin skeletal elements. We provide evidence that the process...

[email protected] ) Competing interests statement The authors declare no competing financial interests. 11 2 2011 © 2011. 2011 Dedifferentiation Gonadogenesis Stem cell niche Drosophila Adult stem cells are necessary for tissue homeostasis, and in most cases are localized...

... 2003 © 2003. 2003 Arabidopsis thaliana Temperature-sensitive mutant Adventitious root formation Cell proliferation Dedifferentiation Root primordium Root apical meristem Auxin microtubule MOR1 During the post-embryonic development of plants, new axes of growth emerge...

... amputation, and is an early molecular marker for dedifferentiation. * Author for correspondence 13 02 1995 © 1995 by Company of Biologists 1995 homeobox HoxA13 HoxA9 urodele axolotl limb development pattern formation limb regeneration retinoic acid dedifferentiation...

... hyaluronidase, passing through the bipotent dedifferentiated state. We have isolated genes that are expressed specifically by either pigment or lens cells and analyzed their expression in the transdifferentiation process. The expression of some proto-oncogenes was also studied. In the dedifferentiation process...

..., but the second time through they will do so in roughly one-tenth the original time, a process known as ‘rapid recapitulation’. However, if disaggre-gated cells are suspended in nutrient medium, they enter a program of dedifferentiation during which they lose the capacity to rapidly recapitulate after an 80...

...Colin M. Casimir; Phillip B. Gates; Roger K. Patient; Jeremy P. Brockes Amphibian limb regeneration is a process in which it has been suggested that cells of one differentiated type may dedifferentiate and give rise to cells of another type in the regenerate. We have used two tissue-specific...

... dedifferentiation newt Notophthalmus viridescens . Adult urodele amphibians are able to regenerate their limbs after amputation by forming a localized growth zone, called a blastema, at the tip of the limb stump. It has been suggested that the cells of the blastema arise by local dedifferentiation...