... 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: A summary of the October 2020 Keystone eSymposia ‘Tissue Plasticity: Preservation and Alteration of Cellular Identity’. Metaplasia Paligenosis Dedifferentiation Transdifferentiation Reprogramming...

... undergo a multipotency switch, they do not make a significant contribution to acinar regeneration. Intriguingly, more than 80% of regenerated acini derive from differentiated cells, including myoepithelial and ductal cells, that appear to dedifferentiate to a progenitor-like state before re...

... relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid cell and vascular pericyte populations in the neonatal testis...

... to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential...

...Karina Geurtzen; Franziska Knopf; Daniel Wehner; Leonie F. A. Huitema; Stefan Schulte-Merker; Gilbert Weidinger Zebrafish have an unlimited capacity to regenerate bone after fin amputation. In this process, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus represent...

... Retinal development Dedifferentiation Pupal eye Transdifferentiation Pigment cell Drosophila Terminal differentiation involves a complex and coordinated sequence of events through which newly specified cells acquire the unique features needed to carry out their specific functions...

.... The blastema is thought to originate from either stem (or progenitor) cells or differentiated cells of various tissues that undergo dedifferentiation. Here, we investigate the origin of cells that contribute to the regeneration of zebrafish caudal fin skeletal elements. We provide evidence that the process...

[email protected]) Competing interests statement The authors declare no competing financial interests. 11 2 2011 © 2011. 2011 Dedifferentiation Gonadogenesis Stem cell niche Drosophila Adult stem cells are necessary for tissue homeostasis, and in most cases are localized...

... for cell proliferation during dedifferentiation of hypocotyl cells, and that their functions are not required for the resumption and subsequent progression of the cell cycle. The RID2 gene may play some essential roles in the second stage of the reinitiation of cell proliferation, i.e...

... amputation, and is an early molecular marker for dedifferentiation. Fig. 2. Expression of HoxA13 and HoxA9 in developing, regenerating and mature axolotl limbs as visualized by northern blot analysis. The sizes of the transcripts were determined relative to the mobility of axolotl 28S rRNA (3.9 kb...

... hyaluronidase, passing through the bipotent dedifferentiated state. We have isolated genes that are expressed specifically by either pigment or lens cells and analyzed their expression in the transdifferentiation process. The expression of some proto-oncogenes was also studied. In the dedifferentiation process...

..., but the second time through they will do so in roughly one-tenth the original time, a process known as ‘rapid recapitulation’. However, if disaggre-gated cells are suspended in nutrient medium, they enter a program of dedifferentiation during which they lose the capacity to rapidly recapitulate after an 80...

...Colin M. Casimir; Phillip B. Gates; Roger K. Patient; Jeremy P. Brockes Amphibian limb regeneration is a process in which it has been suggested that cells of one differentiated type may dedifferentiate and give rise to cells of another type in the regenerate. We have used two tissue-specific...

... Biochemistry, National Institute for Medical Research, The Ridgeway, Mill Hill. London NW7 1AA, UK 11 06 1987 © 1987 by Company of Biologists 1987 minced muscle regeneration pericyte myogenesis 22/18 dedifferentiation newt Notophthalmus viridescens . Adult urodele...