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Keywords: Decidualization
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Journal Articles

Establishment of an in vitro implantation model using a newly developed mouse endometrial organoid

Open Access
Taishi Fujimura, Isao Tamura, Azumi Yoshimura, Toshihide Yoneda, Hitomi Takasaki, Amon Shiroshita, Yuichiro Shirafuta, Shun Sato, Norihiro Sugino
Journal: Development
Development (2025) 152 (9): dev204461.
https://doi.org/10.1242/dev.204461
Published: 14 May 2025
...-lapse imaging revealed the four implantation steps: blastocyst attachment, epithelial invagination, entosis and invasion. Invaded cells expressed proliferin while surrounding stromal cells expressed cyclooxygenase 2, indicating trophoblast differentiation and decidualization. This novel organoid closely...
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Includes: Supplementary data