...Yixin Zang; Greg J. Bashaw ABSTRACT The Netrin receptor Dcc and its Drosophila homolog Frazzled play crucial roles in diverse developmental process, including axon guidance. In Drosophila, Fra regulates midline axon guidance through a Netrin-dependent and a Netrin-independent pathway. However, what...

...Samantha A. Russell; Kaitlin M. Laws; Greg J. Bashaw ABSTRACT The Netrin receptor Frazzled/Dcc (Fra in Drosophila ) functions in diverse tissue contexts to regulate cell migration, axon guidance and cell survival. Fra signals in response to Netrin to regulate the cytoskeleton and also acts...

... mechanisms that control the development of a boundary at the CNS surface and prevent CNS neuron emigration from the neural tube. It has previously been shown that a subset of spinal cord commissural axons abnormally invades sensory nerves in Ntn1 hypomorphic embryos and Dcc knockouts. However, whether netrin...

... functions. However, to date, surprisingly little is known about the molecular-genetic mechanisms that regulate how central axons are confined within the CNS during development. Here, we show that netrin 1/Dcc/Unc5 chemotropism contributes to axonal confinement within the CNS. In both Ntn1 and Dcc mutant...

...Chenxi Tian; Herong Shi; Shan Xiong; Fenghua Hu; Wen-Cheng Xiong; Jun Liu The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions...

... The authors declare no competing financial interests. 12 4 2013 © 2013. Published by The Company of Biologists Ltd 2013 Abelson Netrin Frazzled DCC Axon guidance During nervous system development, embryonic axons navigate through a complex environment to initiate...

...Amy H. Lim; Arminda Suli; Karina Yaniv; Brant Weinstein; Dean Y. Li; Chi-Bin Chien The neural and vascular systems share common guidance cues that have direct and independent signaling effects on nerves and endothelial cells. Here, we show that zebrafish Netrin 1a directs Dcc-mediated axon guidance...

... statement The authors declare no competing financial interests. © 2011. 2011 DCC Adhesion Axon Neogenin Netrin UNC5 Netrins are a family of extracellular, laminin-related (see Glossary, Box 1 ) proteins that function as chemotropic guidance cues for migrating cells and axons...

... membrane expansion and guided membrane extension. To identify genes required for muscle arm extension, we performed a forward screen for mutants with fewer muscle arms. We isolated 23 mutations in 14 genes, including unc-40/Dcc , which encodes a transmembrane receptor that guides the migration of cells...

...Solenn Patalano; Marija Mihailovich; Yaiza Belacortu; Nuria Paricio; Fátima Gebauer Dosage compensation in Drosophila melanogaster involves the assembly of the MSL-2-containing dosage compensation complex (DCC) on the single X chromosome of male flies. Translational repression of msl-2 mRNA blocks...

... and vesicle trafficking. Activation of the RhoA subfamily of Rho GTPases is essential for chemorepellent axon guidance;however, their role during axonal chemoattraction is unclear. Here, we show that netrin 1, through its receptor DCC, inhibits RhoA in embryonic spinal commissural neurons. To determine...

...David S. Garbe; Mike O'Donnell; Greg J. Bashaw The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood. Evidence from...

... afferent neural networks. * Author for correspondence (e-mail: [email protected] ) 3 2 2006 © 2006. 2006 Network formation Dcc Unc5c RCM Dorsal funiculus DRG Mouse Primary sensory axons from the dorsal root ganglion (DRG) convey different types...

...Yu-Qiang Ding; Ji-Young Kim; Yong-Sheng Xu; Yi Rao; Zhou-Feng Chen Neuronal migration and lamina-specific primary afferent projections are crucial for establishing spinal cord circuits, but the underlying mechanisms are poorly understood. Here, we report that in mice lacking Dcc (deleted...